GCK anticorps

N° du produit ABIN966192

Détail du produit anti-GCK anticorps

Antigène: GCK (Glucokinase (Hexokinase 4) (GCK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GCK est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human GCK expressed in E. Coli.

Clone: 4G6

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-GCK (ABIN966192)

Barbetti, Cobo-Vuilleumier, Dionisi-Vici, Toni, Ciampalini, Massa, Rodriguez-Bada, Colombo, Lenzi, Garcia-Gimeno, Bermudez-Silva, Rodriguez de Fonseca, Banin, Aledo, Baixeras, Sanz, Cuesta-Muñoz: "Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene." dans: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 12, pp. 1983-9, (2009) (PubMed).

Yoshida, Kato, Yokoi, Oguri, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nishigaki, Nozawa, Yamada: "Association of genetic variants with chronic kidney disease in individuals with different lipid profiles." dans: International journal of molecular medicine, Vol. 24, Issue 2, pp. 233-46, (2009) (PubMed).

Détails sur GCK

Antigène: GCK (Glucokinase (Hexokinase 4) (GCK))

Autre désignation: GCK (GCK Produits)

Synonymes: anticorps FGQTL3, anticorps GK, anticorps GLK, anticorps HHF3, anticorps HK4, anticorps HKIV, anticorps HXKP, anticorps LGLK, anticorps MODY2, anticorps Gk, anticorps Gls006, anticorps GCK, anticorps BA4487, anticorps glk, anticorps hk4, anticorps hhf3, anticorps hkiv, anticorps hxkp, anticorps gck-A, anticorps mody2, anticorps glucokinase, anticorps GLUKA, anticorps RNGK2, anticorps glucokinase, anticorps glucokinase (hexokinase 4) L homeolog, anticorps glucokinase (hexokinase 4), anticorps GCK, anticorps Gck, anticorps glcK, anticorps Bphyt_1025, anticorps Halhy_6548, anticorps gk, anticorps gck.L, anticorps gck

Sujet: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Synonyms: GK, GLK, HK4, HHF3, HKIV, HXKP, LGLK, MODY2, FGQTL3

Poids moléculaire: 52kDa

ID gène: 2645

Pathways: Signalisation MAPK, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process