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GREM1 anticorps (C-Term)

GREM1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN966222
  • Antigène Voir toutes GREM1 Anticorps
    GREM1 (Gremlin 1 (GREM1))
    Épitope
    • 21
    • 15
    • 14
    • 10
    • 9
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 73
    • 40
    • 23
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 79
    • 8
    • 1
    Lapin
    Clonalité
    • 80
    • 8
    Polyclonal
    Conjugué
    • 38
    • 14
    • 11
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GREM1 est non-conjugé
    Application
    • 80
    • 45
    • 31
    • 13
    • 13
    • 9
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB)
     Réactivité croisée
    Souris, Rat (Rattus)
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Gremlin-1 (GREM1) detection. Tested with WB in Human, Mouse, Rat.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminal of human Gremlin 1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
    Isotype
    IgG
    Top Product
    Discover our top product GREM1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide, Thimerosal (Merthiolate)
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Stabile, Mitola, Moroni, Belleri, Nicoli, Coltrini, Peri, Pessi, Orsatti, Talamo, Castronovo, Waltregny, Cotelli, Ribatti, Presta: "Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor." dans: Blood, Vol. 109, Issue 5, pp. 1834-40, (2007) (PubMed).

    Namkoong, Shin, Kim, Ha, Cho, Hur, Kim, Kim: "The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein." dans: BMC cancer, Vol. 6, pp. 74, (2006) (PubMed).

    Sox: "Office-based testing for fecal occult blood: do only in case of emergency." dans: Annals of internal medicine, Vol. 142, Issue 2, pp. 146-8, (2005) (PubMed).

    Gazzerro, Pereira, Jorgetti, Olson, Economides, Canalis: "Skeletal overexpression of gremlin impairs bone formation and causes osteopenia." dans: Endocrinology, Vol. 146, Issue 2, pp. 655-65, (2005) (PubMed).

  • Antigène
    GREM1 (Gremlin 1 (GREM1))
    Autre désignation
    Gremlin-1 (GREM1 Produits)
    Synonymes
    anticorps grem1, anticorps MGC136702, anticorps zgc:136702, anticorps GREM1, anticorps drm, anticorps pig2, anticorps dand2, anticorps ihg-2, anticorps gremlin, anticorps Cktsf1b1, anticorps Drm, anticorps Grem, anticorps ld, anticorps gremlin-1, anticorps CKTSF1B1, anticorps DAND2, anticorps DRM, anticorps GREMLIN, anticorps IHG-2, anticorps cktsf1b1, anticorps gremlin 1a, DAN family BMP antagonist, anticorps gremlin 1, DAN family BMP antagonist, anticorps gremlin 1, anticorps gremlin 1, DAN family BMP antagonist L homeolog, anticorps grem1a, anticorps GREM1, anticorps LOC662541, anticorps grem1, anticorps Grem1, anticorps grem1.L
    Sujet
    Gremlin, also known as Drm, is a highly conserved 20. 7-kDa, 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein. Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. And Gremlin is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. Gremlin 1 (GREM 1) is known for its antagonistic reaction with BMPs in the TGF beta signaling pathway. This gene inhibits BMP-2, BMP-4, and BMP-7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma. Over-expressed gremlin 1 functions by interaction with YWHAH (Its binding site for gremlin 1 was located between residues 61-80 and gremlin 1 binding site for YWHAH was found to be located between residues 1-67). Therefore, Gremlin 1 and its binding protein YWHAH could be good targets for developing diagnostic and therapeutic strategies against human cancers.
    Pathways
    Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
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