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USP7 anticorps

USP7 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 5F11 unconjugated
N° du produit ABIN966249
  • Antigène Voir toutes USP7 Anticorps
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    Reactivité
    • 100
    • 35
    • 31
    • 8
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 89
    • 9
    • 2
    Souris
    Clonalité
    • 79
    • 21
    Monoclonal
    Conjugué
    • 49
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp USP7 est non-conjugé
    Application
    • 79
    • 38
    • 30
    • 14
    • 14
    • 13
    • 12
    • 10
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    Ascitic fluid
    Immunogène
    Purified recombinant fragment of human HAUSP expressed in E. Coli.
    Clone
    5F11
    Isotype
    IgG1
    Top Product
    Discover our top product USP7 Anticorps primaire
  • Indications d'application
    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
  • Kotoula, Krikelis, Karavasilis, Koletsa, Eleftheraki, Televantou, Christodoulou, Dimoudis, Korantzis, Pectasides, Syrigos, Kosmidis, Fountzilas: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." dans: BMC cancer, Vol. 12, Issue 1, pp. 342, (2012) (PubMed).

    Abély: "[Treatment of airway inflammation in cystic fibrosis]." dans: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Vol. 14, Issue 11, pp. 1350-5, (2007) (PubMed).

    MILLER: "Observations on a case of probable bone marrow anthracosis." dans: Blood, Vol. 14, pp. 1350-3 (PubMed).

  • Antigène
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    Autre désignation
    HAUSP (USP7 Produits)
    Synonymes
    anticorps CG1490, anticorps Dmel\\CG1490, anticorps USP7, anticorps 2210010O09Rik, anticorps AA409944, anticorps AA617399, anticorps AU019296, anticorps AW548146, anticorps C80752, anticorps Hausp, anticorps HAUSP, anticorps TEF1, anticorps UBP, anticorps Ubiquitin-specific protease 7, anticorps ubiquitin carboxyl-terminal hydrolase 7, anticorps ubiquitin specific peptidase 7, anticorps Usp7, anticorps LOC100201254, anticorps USP7
    Sujet
    USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
    Synonyms: TEF1, HAUSP, USP7
    Poids moléculaire
    128kDa
    ID gène
    7874
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