ErbB2/Her2 anticorps
-
- Antigène Voir toutes ErbB2/Her2 Anticorps
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp ErbB2/Her2 est non-conjugé
-
Application
- Immunohistochemistry (IHC)
- Specificité
- HER2 (Ab-1221/1222) antibody detects endogenous levels of total HER2 protein.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogène
- The antiserum was produced against synthesized non-phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine 1221/1222 (N-L-YP-YP -W).
- Top Product
- Discover our top product ErbB2/Her2 Anticorps primaire
-
-
- Indications d'application
-
WB: 1:500~1:1000
IHC: 1:50~1:100. - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 100ug/100ul.
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
-
-
Memo mediates ErbB2-driven cell motility." dans: Nature cell biology, Vol. 6, Issue 6, pp. 515-22, (2004) (PubMed).
: "ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner." dans: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38486-93, (2002) (PubMed).
: "Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2." dans: Cancer research, Vol. 60, Issue 13, pp. 3384-8, (2000) (PubMed).
: "The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling." dans: Carcinogenesis, Vol. 19, Issue 11, pp. 2013-9, (1998) (PubMed).
: "Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: implications for molecular diagnostics." dans: Experimental cell research, Vol. 241, Issue 2, pp. 467-75, (1998) (PubMed).
: "
-
Memo mediates ErbB2-driven cell motility." dans: Nature cell biology, Vol. 6, Issue 6, pp. 515-22, (2004) (PubMed).
-
- Antigène
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
- Autre désignation
- HER2 (ErbB2/Her2 Produits)
- Synonymes
- anticorps CD340, anticorps HER-2, anticorps HER-2/neu, anticorps HER2, anticorps MLN 19, anticorps NEU, anticorps NGL, anticorps TKR1, anticorps Erbb-2, anticorps Neu, anticorps c-erbB2, anticorps c-neu, anticorps mKIAA3023, anticorps wu:fv70f10, anticorps zgc:63601, anticorps erb2, anticorps erb-b2 receptor tyrosine kinase 2, anticorps ERBB2, anticorps Erbb2, anticorps erbb2
- Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
-