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IGF1R anticorps

IGF1R Reactivité: Humain WB, ELISA, IHC Monoclonal unconjugated
N° du produit ABIN966348
  • Antigène Voir toutes IGF1R Anticorps
    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
    Reactivité
    • 197
    • 118
    • 99
    • 16
    • 7
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    Veuillez nous consulter SVP
    Clonalité
    • 183
    • 31
    Monoclonal
    Conjugué
    • 121
    • 10
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp IGF1R est non-conjugé
    Application
    • 131
    • 72
    • 65
    • 60
    • 32
    • 31
    • 17
    • 13
    • 13
    • 10
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    Crude ascites.
    Immunogène
    Ni-NTA purified truncated recombinant IGF1R-His expressed in E. Coli strain BL21 (DE3)
    Isotype
    IgG2b
    Top Product
    Discover our top product IGF1R Anticorps primaire
  • Indications d'application
    Western Blot: 1: 500- 1: 2,000
    IHC(P): 1: 500- 1: 2,000
    IHC(F): 1: 500- 1: 2,000
    ELISA: Propose dilution 1: 10,000.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Stock
    -20 °C
  • Scheidegger, Cenni, Picard, Delafontaine: "Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects." dans: The Journal of biological chemistry, Vol. 275, Issue 49, pp. 38921-8, (2001) (PubMed).

    Fujimoto, Tomita, Wakamatsu, Tanimoto, Ike: "Physical mapping of the conjugative bacteriocin plasmid pPD1 of Enterococcus faecalis and identification of the determinant related to the pheromone response." dans: Journal of bacteriology, Vol. 177, Issue 19, pp. 5574-81, (1995) (PubMed).

  • Antigène
    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
    Autre désignation
    IGF1R (IGF1R Produits)
    Synonymes
    anticorps CMT2N, anticorps CD221, anticorps IGFIR, anticorps IGFR, anticorps JTK13, anticorps IGFIRC, anticorps IGFR1, anticorps IGF-1R, anticorps IGF1R, anticorps DKFZp469I0618, anticorps igf-1r, anticorps xIGF-1R, anticorps xIGFR, anticorps xigf1r, anticorps A330103N21Rik, anticorps D930020L01, anticorps hyft, anticorps igf-ir, anticorps IGF-IR, anticorps IGF-IRb, anticorps wu:fb03h06, anticorps IGF-IRa, anticorps sb:eu1090, anticorps wu:fi20b10, anticorps alanyl-tRNA synthetase, anticorps insulin like growth factor 1 receptor, anticorps insulin-like growth factor 1 receptor, anticorps insulin-like growth factor 1, anticorps insulin-like growth factor I receptor, anticorps insulin like growth factor 1 receptor S homeolog, anticorps insulin-like growth factor 1b receptor, anticorps insulin-like growth factor 1a receptor, anticorps AARS, anticorps IGF1R, anticorps Igf1r, anticorps igf1r, anticorps Igf1, anticorps LOC780503, anticorps LOC100136427, anticorps igf1r.S, anticorps igf1rb, anticorps igf1ra
    Sujet
    IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
    Pathways
    Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy
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