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KSHVORF45 anticorps

Reactivité: Human Herpesvirus 8 (HHV-8) ELISA, WB Monoclonal unconjugated
N° du produit ABIN966465
  • Antigène
    KSHVORF45
    Reactivité
    Human Herpesvirus 8 (HHV-8)
    Hôte
    Veuillez nous consulter SVP
    Clonalité
    • 2
    Monoclonal
    Conjugué
    • 2
    Inconjugué
    Application
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Specificité
    Ni-NTA purified recombinant human KSHV ORF45 expressed in E. Coli strain BL21 (DE3).
    Purification
    Crude ascites.
    Isotype
    IgG1
  • Indications d'application
    Dilution: Western Blot: 1:500-1,000
    ELISA: Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Stock
    -20 °C
  • Zhu, Yuan: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." dans: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).

    Zhu, King, Smith, Levy, Yuan: "A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5573-8, (2002) (PubMed).

    Chang, Cesarman, Pessin, Lee, Culpepper, Knowles, Moore: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." dans: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, (1995) (PubMed).

  • Antigène
    KSHVORF45
    Classe de substances
    Viral Protein
    Sujet
    Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediateearly gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
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