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KSHVORF62 anticorps

Reactivité: Human Herpesvirus 8 (HHV-8) WB, ELISA Monoclonal unconjugated
N° du produit ABIN966466
  • Antigène
    KSHVORF62
    Reactivité
    Human Herpesvirus 8 (HHV-8)
    Hôte
    Veuillez nous consulter SVP
    Clonalité
    • 2
    Monoclonal
    Conjugué
    • 2
    Inconjugué
    Application
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificité
    Ni-NTA purified recombinant human KSHV ORF62 expressed in E. Coli strain BL21 (DE3).
    Purification
    Crude ascites.
    Isotype
    IgM
  • Indications d'application
    Dilution: Western Blot: 1:500-1,000
    ELISA: Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Stock
    -20 °C
  • Wu, Lo, Yu, Stoops, Forghani, Zhou: "Three-dimensional structure of the human herpesvirus 8 capsid." dans: Journal of virology, Vol. 74, Issue 20, pp. 9646-54, (2000) (PubMed).

    Russo, Bohenzky, Chien, Chen, Yan, Maddalena, Parry, Peruzzi, Edelman, Chang, Moore: "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 25, pp. 14862-7, (1997) (PubMed).

    Chang, Cesarman, Pessin, Lee, Culpepper, Knowles, Moore: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." dans: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, (1995) (PubMed).

  • Antigène
    KSHVORF62
    Classe de substances
    Viral Protein
    Sujet
    Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.
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