Lipase A anticorps

N° du produit ABIN966473

Détail du produit anti-Lipase A anticorps

Antigène: Lipase A (LIPA) (Lipase A, Lysosomal Acid, Cholesterol Esterase (LIPA))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp Lipase A est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Ni-NTA purified truncated recombinant LAL expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: Dilution 1: 200- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Références pour anticorps anti-Lipase A (ABIN966473)

Drebber, Andersen, Kasper, Lohse, Stolte, Dienes: "Severe chronic diarrhea and weight loss in cholesteryl ester storage disease: a case report." dans: World journal of gastroenterology : WJG, Vol. 11, Issue 15, pp. 2364-6, (2005) (PubMed).

Boldrini, Devito, Biselli, Filocamo, Bosman: "Wolman disease and cholesteryl ester storage disease diagnosed by histological and ultrastructural examination of intestinal and liver biopsy." dans: Pathology, research and practice, Vol. 200, Issue 3, pp. 231-40, (2004) (PubMed).

Détails sur Lipase A

Antigène: Lipase A (LIPA) (Lipase A, Lysosomal Acid, Cholesterol Esterase (LIPA))

Autre désignation: LAL (LIPA Produits)

Synonymes: anticorps cesd, anticorps lal, anticorps LIPA, anticorps CESD, anticorps LAL, anticorps Chole, anticorps Chole2, anticorps Lip1, anticorps AA960673, anticorps Lal, anticorps Lip-1, anticorps lipase A, lysosomal acid type, anticorps lipase A, lysosomal acid, cholesterol esterase, anticorps lipase A, lysosomal acid, cholesterol esterase L homeolog, anticorps lysosomal acid lipase A, anticorps LIPA, anticorps lipa, anticorps lipa.L, anticorps Lipa

Sujet: Lysosomal acid lipase (LAL), with 378-amino acid protein( 43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.