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Mu Opioid Receptor 1 anticorps (C-Term)

OPRM1 Reactivité: Humain, Souris IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN966719
  • Antigène Voir toutes Mu Opioid Receptor 1 (OPRM1) Anticorps
    Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))
    Épitope
    • 27
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 57
    • 43
    • 20
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 72
    • 3
    • 2
    Lapin
    Clonalité
    • 76
    • 1
    Polyclonal
    Conjugué
    • 38
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Mu Opioid Receptor 1 est non-conjugé
    Application
    • 58
    • 33
    • 30
    • 15
    • 14
    • 13
    • 6
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Immunogène
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very Cterminal residues of human OPRM1(Mu-type opioid receptor)
    Top Product
    Discover our top product OPRM1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Stock
    4 °C
  • Xu, Xu, Hurd, Pasternak, Pan: "Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene." dans: Journal of neurochemistry, Vol. 108, Issue 4, pp. 962-72, (2009) (PubMed).

    Pan, Xu, Yu, Xu, Pan, Pasternak: "Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm." dans: Neuroscience, Vol. 133, Issue 1, pp. 209-20, (2005) (PubMed).

    Pan, Xu, Mahurter, Xu, Gilbert, Pasternak: "Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X." dans: Biochemical and biophysical research communications, Vol. 301, Issue 4, pp. 1057-61, (2003) (PubMed).

    Uhl, Sora, Wang: "The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 14, pp. 7752-5, (1999) (PubMed).

    Mestek, Hurley, Bye, Campbell, Chen, Tian, Liu, Schulman, Yu: "The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 3 Pt 2, pp. 2396-406, (1995) (PubMed).

    Wang, Johnson, Persico, Hawkins, Griffin, Uhl: "Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment." dans: FEBS letters, Vol. 338, Issue 2, pp. 217-22, (1994) (PubMed).

    Bare, Mansson, Yang: "Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain." dans: FEBS letters, Vol. 354, Issue 2, pp. 213-6, (1994) (PubMed).

  • Antigène
    Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))
    Autre désignation
    OPRM1 (OPRM1 Produits)
    Synonymes
    anticorps LMOR, anticorps M-OR-1, anticorps MOP, anticorps MOR, anticorps MOR1, anticorps OPRM, anticorps MOP-R, anticorps MOR-1, anticorps MOR-1O, anticorps Oprm, anticorps mor, anticorps muOR, anticorps MORA, anticorps Oprrm1, anticorps or2, anticorps ZFOR2, anticorps OPRM1, anticorps opioid receptor mu 1, anticorps opioid receptor, mu 1, anticorps outer membrane protein OprM, anticorps OPRM1, anticorps Oprm1, anticorps oprm1, anticorps oprM1
    Sujet
    OPRM1(Mu-type opioid receptor) inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. OPRM1forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. OPRM1 interacts with RGSZ17 and RGSZ20. OPRM1 is a multi-pass membrane protein. The polymorphism Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form. OPRM1(Mu-type opioid receptor) belongs to the G-protein coupled receptor 1 family.
    Pathways
    cAMP Metabolic Process, Synaptic Membrane
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