LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) anticorps

Détails pour le produit réf. ABIN966832, Fournisseur: Connectez-vous pour afficher
Antigène
  • PINCH
  • PINCH-1
  • PINCH1
  • Pinch1
  • RGD1560732
  • LIMS3
  • LIMS3L
  • 2310016J22Rik
  • 4921524A02Rik
  • AI507642
  • AU021743
  • AW551584
  • C430041B13Rik
  • Lims1l
  • LIM zinc finger domain containing 1
  • LIM and senescent cell antigen-like domains 1
  • LIMS1
  • Lims1
Reactivité
Humain
53
32
32
5
4
4
4
4
4
3
3
2
2
2
Hôte
Souris
43
11
Clonalité (Clone)
Monoclonal ()
Conjugué
Inconjugué
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), ELISA, Western Blotting (WB)
38
18
13
13
8
8
6
5
3
1
1
1
Options
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Immunogène Purified recombinant fragment of human PINCH expressed in E. Coli.
Clone 5G7
Isotype IgG1
Purification Ascitic fluid
Autre désignation PINCH (LIMS1 Antibody Extrait)
Sujet The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms: PINCH, PINCH1, PINCH-1, LIMS1
Poids moléculaire 37kDa
ID gène 3987
Indications d'application Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Produit citée dans: Yang, Wang, Hawkins, Chen, Vaynberg, Mao, Tu, Zuo, Wang, Wang, Wu, Tjandra, Qin: "Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase." dans: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5836-44, 2009 (PubMed).

Chiswell, Zhang, Murphy, Boggon, Calderwood: "The structural basis of integrin-linked kinase-PINCH interactions." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 52, pp. 20677-82, 2008 (PubMed).

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