LIMS1 anticorps

N° du produit ABIN966832

Détail du produit anti-LIMS1 anticorps

Antigène: LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LIMS1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human PINCH expressed in E. Coli.

Clone: 5G7

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-LIMS1 (ABIN966832)

Yang, Wang, Hawkins, Chen, Vaynberg, Mao, Tu, Zuo, Wang, Wang, Wu, Tjandra, Qin: "Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase." dans: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5836-44, (2009) (PubMed).

Chiswell, Zhang, Murphy, Boggon, Calderwood: "The structural basis of integrin-linked kinase-PINCH interactions." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 52, pp. 20677-82, (2008) (PubMed).

Détails sur LIMS1

Antigène: LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))

Autre désignation: PINCH (LIMS1 Produits)

Synonymes: anticorps PINCH, anticorps PINCH-1, anticorps PINCH1, anticorps Pinch1, anticorps RGD1560732, anticorps LIMS3, anticorps LIMS3L, anticorps 2310016J22Rik, anticorps 4921524A02Rik, anticorps AI507642, anticorps AU021743, anticorps AW551584, anticorps C430041B13Rik, anticorps Lims1l, anticorps LIM zinc finger domain containing 1, anticorps LIM and senescent cell antigen-like domains 1, anticorps LIMS1, anticorps Lims1

Sujet: The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms: PINCH, PINCH1, PINCH-1, LIMS1

Poids moléculaire: 37kDa

ID gène: 3987