RRM2B anticorps (N-Term)

N° du produit ABIN966974

Détail du produit anti-RRM2B anticorps

Antigène: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRM2B est non-conjugé

Application: Immunohistochemistry (IHC)

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human RRM2B (Ribonucleoside-diphosphate reductase subunit M2B)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-RRM2B (ABIN966974)

Xue, Zhou, Liu, Qiu, Jin, Yen: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." dans: Cancer research, Vol. 63, Issue 5, pp. 980-6, (2003) (PubMed).

Guittet, Håkansson, Voevodskaya, Fridd, Gräslund, Arakawa, Nakamura, Thelander: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." dans: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, (2001) (PubMed).

Yamaguchi, Matsuda, Sagiya, Iwadate, Fujino, Nakamura, Arakawa: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." dans: Cancer research, Vol. 61, Issue 22, pp. 8256-62, (2001) (PubMed).

Détails sur RRM2B

Antigène: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Autre désignation: RRM2B (RRM2B Produits)

Synonymes: anticorps p53r2, anticorps RRM2B, anticorps MTDPS8A, anticorps MTDPS8B, anticorps P53R2, anticorps p53R2, anticorps ribonucleotide reductase M2 B (TP53 inducible) S homeolog, anticorps ribonucleotide reductase regulatory TP53 inducible subunit M2B, anticorps ribonucleotide reductase M2 B (TP53 inducible), anticorps rrm2b.S, anticorps RRM2B, anticorps rrm2b, anticorps Rrm2b

Sujet: RRM2B (Ribonucleoside-diphosphate reductase subunit M2B) plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. RRM2B supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. RRM2B contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. RRM2B binds 2 iron ions per subunit. RRM2B interacts with p53/TP53 and interacts with RRM1 in response to DNA damage. RRM2B is widely expressed at a high level in skeletal muscle and at a weak level in thymus. Defects in RRM2B are the cause of encephalomyopathic mitochondrial depletion syndrome with renal tubulopathy (EMDSRT)
Synonyms: P53R2( p53-inducible ribonucleotide reductase small subunit 2-like protein)

Pathways: Signalisation p53, Negative Regulation of intrinsic apoptotic Signaling