Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

TRKA anticorps (Middle Region)

NTRK1 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN967209
  • Antigène Voir toutes TRKA (NTRK1) Anticorps
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    Épitope
    • 36
    • 26
    • 25
    • 19
    • 16
    • 15
    • 15
    • 10
    • 10
    • 9
    • 8
    • 8
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 239
    • 151
    • 144
    • 15
    • 4
    • 4
    • 1
    • 1
    Humain
    Hôte
    • 248
    • 15
    • 3
    • 2
    Lapin
    Clonalité
    • 240
    • 27
    • 1
    Polyclonal
    Conjugué
    • 102
    • 18
    • 15
    • 13
    • 11
    • 11
    • 11
    • 11
    • 11
    • 11
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TRKA est non-conjugé
    Application
    • 185
    • 99
    • 79
    • 78
    • 51
    • 38
    • 30
    • 20
    • 19
    • 14
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Souris, Rat (Rattus)
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor ( NTRK1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
    Immunogène
    A synthetic peptide corresponding to a sequence in the middle region of human NTRK1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
    Isotype
    IgG
    Top Product
    Discover our top product NTRK1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide, Thimerosal (Merthiolate)
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Lambiase, Merlo, Mollinari, Bonini, Rinaldi, D Amato, Micera, Coassin, Rama, Bonini, Garaci: "Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16795-800, (2005) (PubMed).

    Indo, Tsuruta, Hayashida, Karim, Ohta, Kawano, Mitsubuchi, Tonoki, Awaya, Matsuda: "Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis." dans: Nature genetics, Vol. 13, Issue 4, pp. 485-8, (1996) (PubMed).

    Bonini, Lambiase, Bonini, Angelucci, Magrini, Manni, Aloe: "Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10955-60, (1996) (PubMed).

  • Antigène
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    Autre désignation
    High affinity nerve growth factor receptor (NTRK1) (NTRK1 Produits)
    Synonymes
    anticorps MTC, anticorps TRK, anticorps TRK1, anticorps TRKA, anticorps Trk-A, anticorps p140-TrkA, anticorps CDHF12, anticorps CDHR16, anticorps HSCR1, anticorps MEN2A, anticorps MEN2B, anticorps MTC1, anticorps PTC, anticorps RET-ELE1, anticorps RET51, anticorps Trk, anticorps C80751, anticorps Tkr, anticorps TrkA, anticorps trk, anticorps trka, anticorps CTRKA, anticorps trkA, anticorps neurotrophic receptor tyrosine kinase 1, anticorps ret proto-oncogene, anticorps neurotrophic tyrosine kinase, receptor, type 1, anticorps NTRK1, anticorps RET, anticorps Ntrk1, anticorps ntrk1
    Sujet
    Trk A (Neurotrophic tyrosine kinase receptor A) is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor (NGF). Higher affinity binding of NGFR can achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF4 (Neurotrophin-4) and BDNF, and NTF3 (Neurotrophin-3), respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The absence of TrkA (NGFR) expression was associated with a strong increase in the Sp3 repressor short isoform (s) and a lack of the Sp3 activator long isoform. Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes. Indo et al. (1996) concluded that defects in TRKA cause CIPA (Congenital insensitivity to pain with anhidrosis ) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect (s) of the nervous system.
    Pathways
    Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process
Vous êtes ici:
Support technique