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TRPV1 anticorps (Middle Region)

TRPV1 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN967211
  • Antigène Voir toutes TRPV1 Anticorps
    TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
    Épitope
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 38
    • 28
    • 24
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 53
    • 6
    • 2
    • 2
    Lapin
    Clonalité
    • 58
    • 5
    Polyclonal
    Conjugué
    • 40
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp TRPV1 est non-conjugé
    Application
    • 32
    • 24
    • 13
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
     Réactivité croisée
    Souris, Rat (Rattus)
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Transient receptor potential cation channel subfamily V member 1 ( TRPV1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
    Immunogène
    A synthetic peptide corresponding to a sequence in the middle region of human TRPV1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
    Isotype
    IgG
    Top Product
    Discover our top product TRPV1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide, Thimerosal (Merthiolate)
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Cui, Honore, Zhong, Gauvin, Mikusa, Hernandez, Chandran, Gomtsyan, Brown, Bayburt, Marsh, Bianchi, McDonald, Niforatos, Neelands, Moreland, Decker, Lee, Sullivan, Faltynek: "TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 37, pp. 9385-93, (2006) (PubMed).

    Birder, Nakamura, Kiss, Nealen, Barrick, Kanai, Wang, Ruiz, De Groat, Apodaca, Watkins, Caterina: "Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1." dans: Nature neuroscience, Vol. 5, Issue 9, pp. 856-60, (2002) (PubMed).

    Xue, Yu, Trilk, Jong, Schumacher: "The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants." dans: Genomics, Vol. 76, Issue 1-3, pp. 14-20, (2001) (PubMed).

    Eisenberg, Gresalfi, Riccio, McLaughlin: "Adsorption of monovalent cations to bilayer membranes containing negative phospholipids." dans: Biochemistry, Vol. 18, Issue 23, pp. 5213-23, (1980) (PubMed).

  • Antigène
    TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))
    Autre désignation
    Transient receptor potential cation channel subfamily V member 1 (TRPV1) (TRPV1 Produits)
    Synonymes
    anticorps si:dkey-9e15.2, anticorps VR.5'sv, anticorps Vr1, anticorps Vr1l1, anticorps VR1, anticorps OTRPC1, anticorps TRPV1alpha, anticorps TRPV1beta, anticorps VR-1, anticorps transient receptor potential cation channel, subfamily V, member 1, anticorps transient receptor potential cation channel subfamily V member 1, anticorps trpv1, anticorps Trpv1, anticorps TRPV1
    Sujet
    The transient receptor potential cation channel, subfamily V, member 1 (TRPV1), also known as the capsaicin receptor is a protein which in humans is encoded by the TRPV1 gene. TRPV1 (also called Vanilloid receptor type 1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary afferents, TRPV1 is also expressed in the CNS. Cui M et al. (2006) demonstrate that TRPV1 receptors in the CNS play an important role in pain mediated by central sensitization. And the significant CNS penetration is necessary for a TRPV1 antagonist to produce broad-spectrum analgesia. And TRPV1 also participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.
    Pathways
    Dicarboxylic Acid Transport
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