WWOX anticorps (N-Term)

N° du produit ABIN967262

Détail du produit anti-WWOX anticorps

Antigène: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WWOX est non-conjugé

Application: Immunohistochemistry (IHC)

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human WWOX (WW domain-containing oxidoreductase)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-WWOX (ABIN967262)

Park, Ludes-Meyers, Zimonjic, Durkin, Popescu, Aldaz: "Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma." dans: British journal of cancer, Vol. 91, Issue 4, pp. 753-9, (2004) (PubMed).

Chang, Doherty, Ensign: "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis." dans: The Journal of biological chemistry, Vol. 278, Issue 11, pp. 9195-202, (2003) (PubMed).

Bednarek, Keck-Waggoner, Daniel, Laflin, Bergsagel, Kiguchi, Brenner, Aldaz: "WWOX, the FRA16D gene, behaves as a suppressor of tumor growth." dans: Cancer research, Vol. 61, Issue 22, pp. 8068-73, (2001) (PubMed).

Paige, Taylor, Taylor, Hillier, Farrington, Scott, Porteous, Smyth, Gabra, Watson: "WWOX: a candidate tumor suppressor gene involved in multiple tumor types." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11417-22, (2001) (PubMed).

Bednarek, Laflin, Daniel, Liao, Hawkins, Aldaz: "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer." dans: Cancer research, Vol. 60, Issue 8, pp. 2140-5, (2000) (PubMed).

Ried, Finnis, Hobson, Mangelsdorf, Dayan, Nancarrow, Woollatt, Kremmidiotis, Gardner, Venter, Baker, Richards: "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells." dans: Human molecular genetics, Vol. 9, Issue 11, pp. 1651-63, (2000) (PubMed).

Détails sur WWOX

Antigène: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Autre désignation: WWOX (WWOX Produits)

Synonymes: anticorps CG7221, anticorps DmWWOX, anticorps Dmel\\CG7221, anticorps anon-EST:Posey177, anticorps GB11795, anticorps WWOX, anticorps D16S432E, anticorps FOR, anticorps FRA16D, anticorps HHCMA56, anticorps PRO0128, anticorps SDR41C1, anticorps WOX1, anticorps zgc:55975, anticorps 5330426P09Rik, anticorps 9030416C10Rik, anticorps WW domain containing oxidoreductase, anticorps WW domain-containing oxidoreductase, anticorps Wwox, anticorps LOC411815, anticorps WWOX, anticorps CpipJ_CPIJ004939, anticorps MCYG_01584, anticorps VDBG_05631, anticorps VDBG_01326, anticorps VDBG_06753, anticorps Tsp_03967, anticorps LOC100284583, anticorps wwox

Sujet: WWOX (WW domain-containing oxidoreductase) is a probable oxidoreductase, which acts as a tumor suppressor and plays a role in apoptosis. WWOX may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. WWOX may also play a role in tumor necrosis factor (TNF)-mediated cell death.WWOX interacts with TP53, TP73/p73 and MAPK8. WWOX forms a ternary complex with TP53 and MDM2. WWOX is widely expressed and strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Defects in WWOX may be involved in several cancer types. Defects in WWOX may be involved in esophageal squamous cell carcinoma (ESCC)
Synonyms: FOR, WOX1