SLC39A4
Reactivité: Humain
ELISA
Hôte: Lapin
Polyclonal
HRP
Restrictions
For Research Use only
Stock
4 °C
Kim, Wang, Dufner-Beattie, Andrews, Eide, Petris: "Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane." dans: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4523-30, (2004) (PubMed).
Küry, Dréno, Bézieau, Giraudet, Kharfi, Kamoun, Moisan: "Identification of SLC39A4, a gene involved in acrodermatitis enteropathica." dans: Nature genetics, Vol. 31, Issue 3, pp. 239-40, (2002) (PubMed).
Wang, Zhou, Kuo, Zemansky, Gitschier: "A novel member of a zinc transporter family is defective in acrodermatitis enteropathica." dans: American journal of human genetics, Vol. 71, Issue 1, pp. 66-73, (2002) (PubMed).
Antigène
SLC39A4
(Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4))
anticorps AEZ, anticorps AWMS2, anticorps ZIP4, anticorps 1600025H15Rik, anticorps AU041686, anticorps solute carrier family 39 member 4, anticorps solute carrier family 39 (zinc transporter), member 4, anticorps SLC39A4, anticorps slc39a4, anticorps Slc39a4
Sujet
ZIP4 (Zinc transporter ZIP4) plays an important role in cellular zinc homeostasis as a zinc transporter. ZIP4 is regulated in response to zinc availability. ZIP4 is a multi-pass membrane protein and is colocalized with TFRC in the recycling endosomes. ZIP4 cycles between endosomal compartments and the plasma membrane in response to zinc availability. ZIP4 is highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. ZIP4 belongs to the ZIP transporter (TC 2.A.5) family. Synonyms: SLC39A4 (Solute carrier family 39 member 4), ZIP-4 (Zrt- and Irt-like protein 4)