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Cyclin A anticorps

CCNA2 Reactivité: Humain WB, FACS, IP Hôte: Souris Monoclonal BF683 unconjugated
N° du produit ABIN967424
  • Antigène Voir toutes Cyclin A (CCNA2) Anticorps
    Cyclin A (CCNA2) (Cyclin A2 (CCNA2))
    Reactivité
    • 91
    • 56
    • 33
    • 28
    • 14
    • 14
    • 12
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 59
    • 36
    • 1
    Souris
    Clonalité
    • 48
    • 48
    Monoclonal
    Conjugué
    • 69
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cyclin A est non-conjugé
    Application
    • 59
    • 31
    • 21
    • 19
    • 18
    • 17
    • 17
    • 10
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
    Marque
    BD Pharmingen™
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    3. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Cyclin A Recombinant Protein
    Clone
    BF683
    Isotype
    IgE
    Top Product
    Discover our top product CCNA2 Anticorps primaire
  • Commentaires

    Related Products: ABIN968586, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Gong, Bhatia, Traganos, Darzynkiewicz: "Expression of cyclins A, D2 and D3 in individual normal mitogen stimulated lymphocytes and in MOLT-4 leukemic cells analyzed by multiparameter flow cytometry." dans: Leukemia, Vol. 9, Issue 5, pp. 893-9, (1995) (PubMed).

    Gong, Traganos, Darzynkiewicz: "Discrimination of G2 and mitotic cells by flow cytometry based on different expression of cyclins A and B1." dans: Experimental cell research, Vol. 220, Issue 1, pp. 226-31, (1995) (PubMed).

    Faha, Harlow, Lees: "The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2." dans: Journal of virology, Vol. 67, Issue 5, pp. 2456-65, (1993) (PubMed).

    Sherr: "Mammalian G1 cyclins." dans: Cell, Vol. 73, Issue 6, pp. 1059-65, (1993) (PubMed).

    Cao, Faha, Dembski, Tsai, Harlow, Dyson: "Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F." dans: Nature, Vol. 355, Issue 6356, pp. 176-9, (1992) (PubMed).

    Faha, Ewen, Tsai, Livingston, Harlow: "Interaction between human cyclin A and adenovirus E1A-associated p107 protein." dans: Science (New York, N.Y.), Vol. 255, Issue 5040, pp. 87-90, (1992) (PubMed).

  • Antigène
    Cyclin A (CCNA2) (Cyclin A2 (CCNA2))
    Autre désignation
    Cyclin A (CCNA2 Produits)
    Synonymes
    anticorps CCN1, anticorps CCNA, anticorps AA408589, anticorps Ccn-1, anticorps Ccn1, anticorps Ccna, anticorps CycA2, anticorps Cyca, anticorps cb671, anticorps chunp6924, anticorps wu:fi36f03, anticorps CYCA, anticorps Cyclin-A2, anticorps ccna2, anticorps ccn1, anticorps ccna, anticorps ccna1, anticorps Cyclin-A, anticorps cyclinA, anticorps cyclin A2, anticorps cyclin A2 S homeolog, anticorps cyclin A2 L homeolog, anticorps CCNA2, anticorps Ccna2, anticorps ccna2, anticorps ccna2.S, anticorps ccna2.L
    Sujet
    Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl and SV40 large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb), nucleolin and others. Cyclin A is involved in both S-phase and G2/M transitions of the cell cycle through its association with cdk2 and cdk1, respectively. Cyclin A may also form a complex with the adenovirus oncoprotein E1A which has DNA binding activity. Human cyclin A has been reported to migrate between 54-60 kDa by SDS-PAGE and clone BF683 reportedly does not cross-react with mouse, rat or mink cyclin A.
    Poids moléculaire
    54-60 kDa
    Pathways
    Signalisation PI3K-Akt, Cycle Cellulaire, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
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