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Caspase 4 anticorps

CASP4 Reactivité: Humain WB Hôte: Souris Monoclonal B25-1 unconjugated
N° du produit ABIN967534
  • Antigène Voir toutes Caspase 4 (CASP4) Anticorps
    Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
    Reactivité
    • 58
    • 34
    • 15
    • 14
    • 1
    Humain
    Hôte
    • 78
    • 10
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 77
    • 14
    Monoclonal
    Conjugué
    • 54
    • 15
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp Caspase 4 est non-conjugé
    Application
    • 74
    • 29
    • 27
    • 12
    • 9
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB)
    Marque
    BD Pharmingen™
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Recombinant Human Caspase-4
    Clone
    B25-1
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CASP4 Anticorps primaire
  • Indications d'application
    Applications include western blot analysis (1-2 µg/ml). Jurkat T cells (ATCC TIB- 152) and 293 adenovirus-transformed human kidney cells (ATCC CRL-1573) are suggested as positive controls.
    Commentaires

    Related Products: ABIN967389, ABIN968537

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Faucheu, Diu, Chan, Blanchet, Miossec, Hervé, Collard-Dutilleul, Gu, Aldape, Lippke: "A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells." dans: The EMBO journal, Vol. 14, Issue 9, pp. 1914-22, (1995) (PubMed).

    Munday, Vaillancourt, Ali, Casano, Miller, Molineaux, Yamin, Yu, Nicholson: "Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases." dans: The Journal of biological chemistry, Vol. 270, Issue 26, pp. 15870-6, (1995) (PubMed).

  • Antigène
    Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
    Autre désignation
    Caspase-4 (CASP4 Produits)
    Synonymes
    anticorps ICE(rel)II, anticorps ICEREL-II, anticorps ICH-2, anticorps Mih1/TX, anticorps TX, anticorps Casp11, anticorps CASP13, anticorps CASP1, anticorps CASP4, anticorps Caspl, anticorps ich-3, anticorps Casp4, anticorps caspase 4, anticorps caspase 4, apoptosis-related cysteine peptidase, anticorps caspase-4, anticorps CASP4, anticorps Casp4, anticorps LOC100731032
    Sujet
    Caspase-4 (ICErelII, TX, ICH-2) is a 43 kDa cytosolic protein with homology to the ICE/Ced-3 family of cysteine proteases. Functional similarity with ICE proteases include the ability of Caspase-4 to induce apoptosis when overexpressed. Caspase-4 exhibits protease activity, cleaving both itself and the p30 ICE/caspase-1 proenzyme. However, unlike ICE/caspase-1, caspase-4 displays no IL-1beta processing activity. Caspase-4 mRNA is expressed in most adult human tissues, suggesting a broad tissue distribution. The B25-1 antibody recognizes an ~43 kDa band corresponding to human Caspase-4 (TX). A recombinant human Caspase-4 protein fragment corresponding to amino acids 334-377 was used as immunogen.
    Synonyms: TX, Ich-2
    Poids moléculaire
    43 kDa
    Pathways
    Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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