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SNCA anticorps (pTyr125, Tyr125)

SNCA Reactivité: Humain WB Hôte: Souris Monoclonal I57-628 unconjugated
N° du produit ABIN967584
  • Antigène Voir toutes SNCA Anticorps
    SNCA (Synuclein, alpha (SNCA))
    Épitope
    • 73
    • 32
    • 27
    • 23
    • 16
    • 15
    • 13
    • 11
    • 11
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr125, Tyr125
    Reactivité
    • 308
    • 209
    • 209
    • 14
    • 10
    • 10
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 247
    • 103
    • 6
    • 1
    • 1
    • 1
    Souris
    Clonalité
    • 231
    • 129
    Monoclonal
    Conjugué
    • 159
    • 25
    • 22
    • 17
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    Cet anticorp SNCA est non-conjugé
    Application
    • 251
    • 171
    • 113
    • 84
    • 80
    • 74
    • 68
    • 54
    • 49
    • 49
    • 23
    • 21
    • 13
    • 9
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Marque
    BD Pharmingen™
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    3. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Phosphorylated peptide corresponding to the region including the Tyrosine 125 residue of alpha-Synuclein
    Clone
    I57-628
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product SNCA Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Forman, Trojanowski, Lee: "Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs." dans: Nature medicine, Vol. 10, Issue 10, pp. 1055-63, (2004) (PubMed).

    Nakamura, Yamashita, Nagano, Takahashi, Avraham, Avraham, Matsumoto, Nakamura: "Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases." dans: FEBS letters, Vol. 521, Issue 1-3, pp. 190-4, (2002) (PubMed).

    Takahashi, Yamashita, Nakamura, Nagano, Nakamura: "Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress." dans: Brain research, Vol. 938, Issue 1-2, pp. 73-80, (2002) (PubMed).

    Ellis, Schwartzberg, Grider, Fink, Nussbaum: "alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases." dans: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 3879-84, (2001) (PubMed).

    Nakamura, Yamashita, Takahashi, Nakamura: "Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125." dans: Biochemical and biophysical research communications, Vol. 280, Issue 4, pp. 1085-92, (2001) (PubMed).

  • Antigène
    SNCA (Synuclein, alpha (SNCA))
    Autre désignation
    alpha Synuclein (SNCA Produits)
    Synonymes
    anticorps snca, anticorps MGC64356, anticorps LOC619283, anticorps NACP, anticorps alphaSYN, anticorps PARK1, anticorps PARK4, anticorps PD1, anticorps synuclein alpha L homeolog, anticorps alpha-synuclein, anticorps synuclein alpha, anticorps synuclein, alpha, anticorps snca.L, anticorps LOC619283, anticorps SNCA, anticorps Snca
    Sujet
    The 140-amino-acid alpha-Synuclein protein is identical to the non-amyloid-beta component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). This protein is expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. The Tyrosine 125 (Y125) residue of alpha-Synuclein plays an important role in stress-induced dimerization of the protein and is phosphorylated by Pyk/RAFTK via the Src-family kinases Fyn and c-Src.
    The I57-628 antibody recognizes alpha-Synuclein phosphorylated at Y125.
    Poids moléculaire
    19 kDa
    Pathways
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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