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IRS1 anticorps (pTyr896)

IRS1 Reactivité: Humain WB Hôte: Souris Monoclonal K9-211 unconjugated
N° du produit ABIN967601
  • Antigène Voir toutes IRS1 Anticorps
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    Épitope
    • 31
    • 28
    • 23
    • 21
    • 21
    • 20
    • 19
    • 17
    • 16
    • 16
    • 16
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr896
    Reactivité
    • 294
    • 237
    • 213
    • 23
    • 19
    • 18
    • 17
    • 16
    • 16
    • 15
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 292
    • 16
    Souris
    Clonalité
    • 285
    • 23
    Monoclonal
    Conjugué
    • 140
    • 14
    • 13
    • 12
    • 12
    • 12
    • 12
    • 12
    • 11
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    Cet anticorp IRS1 est non-conjugé
    Application
    • 174
    • 126
    • 104
    • 93
    • 92
    • 67
    • 58
    • 53
    • 24
    • 20
    • 13
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Marque
    BD Pharmingen™
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Phosphorylated Human IRS-1 Peptide
    Clone
    K9-211
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product IRS1 Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Gual, Le Marchand-Brustel, Tanti: "Positive and negative regulation of insulin signaling through IRS-1 phosphorylation." dans: Biochimie, Vol. 87, Issue 1, pp. 99-109, (2005) (PubMed).

    White: "IRS proteins and the common path to diabetes." dans: American journal of physiology. Endocrinology and metabolism, Vol. 283, Issue 3, pp. E413-22, (2002) (PubMed).

    Burks, White: "IRS proteins and beta-cell function." dans: Diabetes, Vol. 50 Suppl 1, pp. S140-5, (2001) (PubMed).

    Paz, Liu, Shorer, Hemi, LeRoith, Quan, Kanety, Seger, Zick: "Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function." dans: The Journal of biological chemistry, Vol. 274, Issue 40, pp. 28816-22, (1999) (PubMed).

    Ward, Gough, Rashke, Wan, Tribbick, Wang: "Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor." dans: The Journal of biological chemistry, Vol. 271, Issue 10, pp. 5603-9, (1996) (PubMed).

  • Antigène
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    Autre désignation
    IRS-1 (IRS1 Produits)
    Synonymes
    anticorps HIRS-1, anticorps G972R, anticorps IRS-1, anticorps IRS1IRM, anticorps irs1, anticorps irsu, anticorps IRS1, anticorps irs-1, anticorps irs1-a, anticorps insulin receptor substrate 1, anticorps insulin receptor substrate 2, anticorps insulin receptor substrate 1 S homeolog, anticorps IRS1, anticorps Irs1, anticorps irs2, anticorps irs1.S
    Sujet
    The IRS (Insulin Receptor Substrate) proteins IRS-1, IRS-2, IRS-3, and IRS-4 are major substrates of the insulin receptor and the insulin-like growth factor-1 (IGF-1) receptor tyrosine kinases. IRS proteins contain an N-terminal pleckstrin homology (PH) domain, a phosphotyrosine-binding (PTB) domain, and multiple tyrosine phosphorylation sites in the C-terminus. The IRS-1 protein is widely expressed and, along with IRS-2, mediates somatic growth and carbohydrate metabolic responses to insulin. Following insulin receptor ligation, IRS-1 binds to the juxtamembrane region of the receptor via the PH and PTB domains and is tyrosine phosphorylated, which facilitates its interaction with SH2 domain-containing signaling proteins. Specifically, the phosphorylated tyrosine 896 (pY896) of human IRS-1 is a major binding site for the GRB2 (Growth-factor Receptor-Bound protein 2) adaptor protein. After IRS-1 activation, negative and positive feedback regulates dephosphorylation of its tyrosine sites, which ultimately regulates the magnitude and/or duration of the downstream pleiotropic responses to insulin and IGF-1.
    The K9-211 monoclonal antibody recognizes pY896 of human IRS-1. The orthologous phosphorylation sites of mouse and rat IRS-1 are Y891 and Y895, respectively.
    Poids moléculaire
    160-185 kDa
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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