TYK2 anticorps (pTyr1054)

N° du produit ABIN967611

Détail du produit anti-TYK2 anticorps

Antigène: TYK2 (Tyrosine Kinase 2 (TYK2))

Épitope: pTyr1054

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TYK2 est non-conjugé

Application: Western Blotting (WB)

Marque: BD Pharmingen™

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Phosphorylated peptide of the region including the tyrosines 1054 and 1055 of human Tyk2

Clone: I114-617

Isotype: IgG1 kappa

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-TYK2 (ABIN967611)

Gauzzi, Velazquez, McKendry, Mogensen, Fellous, Pellegrini: "Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase." dans: The Journal of biological chemistry, Vol. 271, Issue 34, pp. 20494-500, (1996) (PubMed).

Détails sur TYK2

Antigène: TYK2 (Tyrosine Kinase 2 (TYK2))

Autre désignation: Tyk2 (TYK2 Produits)

Synonymes: anticorps JTK1, anticorps tyrosine kinase 2, anticorps TYK2, anticorps Tyk2

Sujet: Tyk2 is a widely expressed protein tyrosine kinase (PTK) of 1187 amino acids (135 kDa). The N-terminal kinase-related domain of Tyk2 shows 54% identity to the kinase-related domain of the JAK1 kinase. Surprisingly, the catalytic region of JAK1 shares more sequence identity to Tyk2 than it does with JAK2 kinase. The similarity of structure between Tyk2 and JAK1 suggests that both may be involved in related phosphorylation cascades. Tyk2 plays a critical role in the interferon (IFN)-a/b response while JAK1 shows involvement in both the IFN- a/b and IFN-g signal transduction pathways. JAK2, however, appears to be required only in the IFN-g response. It has been suggested that a portion of the large extracatalytic domain of Tyk2 could interact with components of the IFN a/b receptor.
The I114-617 monoclonal antibody recognizes the phosphorylated Y1054 and Y1055 in the tyrosine kinase domain of Tyk2.

Poids moléculaire: 135 kDa

Pathways: Signalistation JAK/STAT, Hepatitis C