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CD247 anticorps (pTyr142)

CD247 Reactivité: Humain WB Hôte: Souris Monoclonal K25-407-69 unconjugated
N° du produit ABIN967618
  • Antigène Voir toutes CD247 Anticorps
    CD247 (CD247 Molecule (CD247))
    Épitope
    • 16
    • 14
    • 8
    • 8
    • 7
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr142
    Reactivité
    • 101
    • 48
    • 21
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 75
    • 24
    • 6
    • 1
    Souris
    Clonalité
    • 73
    • 33
    Monoclonal
    Conjugué
    • 60
    • 10
    • 8
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CD247 est non-conjugé
    Application
    • 77
    • 53
    • 36
    • 14
    • 14
    • 11
    • 7
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Marque
    BD Pharmingen™
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Phosphorylated Human CD3zeta Peptide
    Clone
    K25-407-69
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product CD247 Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C.
  • Salomon, Ficarro, Brill, Brinker, Phung, Ericson, Sauer, Brock, Horn, Schultz, Peters: "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 443-8, (2003) (PubMed).

    Ernst, Shih: "CD3 complex." dans: Journal of biological regulators and homeostatic agents, Vol. 14, Issue 3, pp. 226-9, (2001) (PubMed).

    Kersh, Shaw, Allen: "Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation." dans: Science (New York, N.Y.), Vol. 281, Issue 5376, pp. 572-5, (1998) (PubMed).

    Alberola-Ila, Takaki, Kerner, Perlmutter: "Differential signaling by lymphocyte antigen receptors." dans: Annual review of immunology, Vol. 15, pp. 125-54, (1997) (PubMed).

  • Antigène
    CD247 (CD247 Molecule (CD247))
    Autre désignation
    CD247 (CD3z) (CD247 Produits)
    Synonymes
    anticorps CD3-ZETA, anticorps CD3H, anticorps CD3Q, anticorps CD3Z, anticorps T3Z, anticorps TCRZ, anticorps 4930549J05Rik, anticorps A430104F18Rik, anticorps AW552088, anticorps Cd3, anticorps Cd3-eta, anticorps Cd3-zeta, anticorps Cd3h, anticorps Cd3z, anticorps Cd3zeta, anticorps T3z, anticorps Tcrk, anticorps Tcrz, anticorps LOC100136514, anticorps LOC100136549, anticorps LOC100305023, anticorps CD247, anticorps TCRzeta, anticorps CD247 molecule, anticorps CD247 antigen, anticorps CD3zeta-2, anticorps CD3zeta-1, anticorps Cd247 molecule, anticorps CD247, anticorps Cd247, anticorps cd3z, anticorps cd247
    Sujet
    The T cell receptor (TCR), expressed by thymocytes and T lymphocytes, is a multi-component cell-surface complex responsible for recognizing antigen in the context of MHC molecules. The antigen-specific binding component of the TCR, Ti, is a heterodimer of the variable Ig-like subunits a and b or g and d. Ti is non-covalently associated with an invariant set of molecules referred to as the CD3 polypeptides, g, d, e, and zeta. The CD3 z polypeptide (CD3z) was named CD247 at the 7th Human Leukocyte Differentiation Antigens Workshop. CD3 appears early in thymocyte differentiation and remains expressed on all mature T lymphocytes. After antigen recognition by the TCR, CD3z is the primary intracellular signal transducing subunit. It contains three ITAMs (Immunoreceptor Tyrosine-based Activation Motifs), each of which contains a pair of tyrosine residues that are phosphorylated by Lck and Fyn and are required for signal propagation. The molecular weight of CD3z is 16 kDa, and it is also observed as 32-kDa homodimers or as heterodimers with the g chain of Fc receptors. Upon phosphorylation, the CD3z monomer undergoes an apparent shift in electrophoretic mobility up to 21 kDa. The K25-407.69 monoclonal antibody recognizes the phosphorylated tyrosine 142 (pY142) in the third ITAM domain of human CD3z (CD247).
    Synonyms: CD3zeta
    Poids moléculaire
    21 kDa
    Pathways
    TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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