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ANK2 anticorps

ANK2 Reactivité: Humain, Rat WB, ELISA, FM Hôte: Souris Monoclonal 2-20 unconjugated
N° du produit ABIN967633
  • Antigène Voir toutes ANK2 Anticorps
    ANK2 (Ankyrin 2, Neuronal (ANK2))
    Reactivité
    • 26
    • 14
    • 13
    • 2
    Humain, Rat
    Hôte
    • 28
    • 1
    Souris
    Clonalité
    • 28
    • 1
    Monoclonal
    Conjugué
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp ANK2 est non-conjugé
    Application
    • 27
    • 26
    • 14
    • 13
    • 10
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Fluorescence Microscopy (FM)
    Marque
    BD Pharmingen™
     Réactivité croisée
    Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Ankyrin B Spectrin Binding Domain Peptide
    Clone
    2-20
    Isotype
    IgG1
    Top Product
    Discover our top product ANK2 Anticorps primaire
  • Indications d'application
    Neonatal rat brain membranes are suggested for use as the positive control.
    Commentaires

    Related Products: ABIN967389, ABIN968545, ABIN968546

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4° C.
  • Scotland, Zhou, Benveniste, Bennett: "Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons." dans: The Journal of cell biology, Vol. 143, Issue 5, pp. 1305-15, (1999) (PubMed).

    Kordeli, Lambert, Bennett: "AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier." dans: The Journal of biological chemistry, Vol. 270, Issue 5, pp. 2352-9, (1995) (PubMed).

    Bennett, Gilligan: "The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane." dans: Annual review of cell biology, Vol. 9, pp. 27-66, (1994) (PubMed).

    Otto, Kunimoto, McLaughlin, Bennett: "Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes." dans: The Journal of cell biology, Vol. 114, Issue 2, pp. 241-53, (1991) (PubMed).

    Kordeli, Davis, Trapp, Bennett: "An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves." dans: The Journal of cell biology, Vol. 110, Issue 4, pp. 1341-52, (1990) (PubMed).

  • Antigène
    ANK2 (Ankyrin 2, Neuronal (ANK2))
    Autre désignation
    Ankyrin B (ANK2 Produits)
    Synonymes
    anticorps ANK-2, anticorps LQT4, anticorps brank-2, anticorps AI835472, anticorps AW491075, anticorps Ank-2, anticorps Ank3, anticorps CHANK2, anticorps ANK2, anticorps ank2, anticorps zgc:101738, anticorps ANKB, anticorps ankyrin 2, anticorps ankyrin 2, brain, anticorps ankyrin-2, anticorps ankyrin 2b, neuronal, anticorps ANK2, anticorps Ank2, anticorps LOC539238, anticorps ank2b, anticorps LOC100465763
    Sujet
    Ankyrins are a family of proteins which were first discovered in erythrocytes and shown to bind to spectrin, a primary component of the cytoskeletal architecture. They have since been shown to be expressed at very high levels in the vertebrate brain and are also found in other cell types. Ankyrins function by acting as adaptors to link integral membrane proteins, including cell adhesion and ion channel molecules to the cytoskeleton. The structure of ankyrin consists of three domains, two highly conserved N-terminal and one C-terminal variable domain. The conserved regions contain a membrane-binding domain of ~89-95 kDa and a spectrin-binding domain of ~62 kDa, while the variable region has pre-mRNA alternative splice sites. Two ankyrins have been extensively characterized: ankryin R is the product of the ANK1 gene and is primarily expressed in the brain, although alternatively spliced forms are found in erythrocytes, ankyrin B is the product of the ANK2 gene, located on a different chromosome from ANK1, and is primarly expressed in neonatal and adult brain but is also found in heart, lymphocytes and platelets. Studies done on ankyrinB (-/-) knockout mice, which die by postnatal day 21, have demonstrated a link between the L1 cell adhesion molecule and ankyrin B in premyelinated axons. Isoforms of ankyrin B have been reported to be detectable ranging from approximately 440, 220, 150 and 110 kDa in western blot analysis, depending on the tissue-type of origin. This antibody is routinely tested by western blot analysis.
    Poids moléculaire
    110-440 kDa
    Pathways
    Cell-Cell Junction Organization
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