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Fibronectin anticorps

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poulet, Chien WB, IHC, IP, IF Hôte: Souris Monoclonal 10-Fibronectin unconjugated
N° du produit ABIN967729
  • Antigène Voir toutes Fibronectin Anticorps
    Fibronectin
    Reactivité
    • 107
    • 57
    • 57
    • 24
    • 14
    • 9
    • 4
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Poulet, Chien
    Hôte
    • 73
    • 60
    • 5
    • 1
    Souris
    Clonalité
    • 73
    • 65
    Monoclonal
    Conjugué
    • 61
    • 19
    • 9
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Fibronectin est non-conjugé
    Application
    • 72
    • 42
    • 39
    • 32
    • 26
    • 20
    • 18
    • 18
    • 18
    • 17
    • 14
    • 13
    • 10
    • 7
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
     Réactivité croisée
    Boeuf (Vache), Poulet, Chien, Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    5. For fluorochrome spectra and suitable instrument settings, please refer to us.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Fibronectin
    Clone
    10-Fibronectin
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product Fibronectin Anticorps primaire
  • Commentaires

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Danen, Sonneveld, Brakebusch, Fassler, Sonnenberg: "The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis." dans: The Journal of cell biology, Vol. 159, Issue 6, pp. 1071-86, (2002) (PubMed).

    Rhee, Sen, Lu, Wu, Leoni, Rubin, Corr, Carson: "Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas." dans: Oncogene, Vol. 21, Issue 43, pp. 6598-605, (2002) (PubMed).

    Zuk, Bonventre, Brown, Matlin: "Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney." dans: The American journal of physiology, Vol. 275, Issue 3 Pt 1, pp. C711-31, (1998) (PubMed).

    Chen, Mosher: "Formation of sodium dodecyl sulfate-stable fibronectin multimers. Failure to detect products of thiol-disulfide exchange in cyanogen bromide or limited acid digests of stabilized matrix fibronectin." dans: The Journal of biological chemistry, Vol. 271, Issue 15, pp. 9084-9, (1996) (PubMed).

    Sechler, Takada, Schwarzbauer: "Altered rate of fibronectin matrix assembly by deletion of the first type III repeats." dans: The Journal of cell biology, Vol. 134, Issue 2, pp. 573-83, (1996) (PubMed).

  • Antigène
    Fibronectin
    Abstract
    Fibronectin Produits
    Synonymes
    anticorps FN, anticorps cig, anticorps fibronectin, anticorps finc, anticorps lets, anticorps msf, anticorps CIG, anticorps ED-B, anticorps FINC, anticorps FNZ, anticorps GFND, anticorps GFND2, anticorps LETS, anticorps MSF, anticorps E330027I09, anticorps Fn, anticorps Fn-1, anticorps FIBNEC, anticorps fn-1, anticorps fibronectin 1, anticorps FN1, anticorps fn1, anticorps Fn1
    Sujet
    The 240 kDa dimeric fibronectin protein exists in two forms: a soluble protomer in body fluids and an insoluble multimer in the extracellular matrix. The latter is the primary functional form and creates a substrate for cell migration, a role which makes fibronectin vital to embryogenesis and wound response. Fibronectin mediates cytoskeletal organization, cell attachment, and cellular signaling through interactions with cellular receptors. Although various isoforms of fibronectin are derived by alternative splicing, they share a common N-terminus which is a critical region for cell surface binding in an initial step of multimer assembly. Further polymerization steps are regulated by fibronectin/integrin interactions and result in generation of the complex fibrils that constitute the fibronectin matrix.
    Synonyms: FN, LETS
    Poids moléculaire
    240 kDa
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