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EPS8 anticorps (AA 628-821)

EPS8 Reactivité: Humain, Rat, Souris, Chien WB, IHC, IF, IP Hôte: Souris Monoclonal 15-Eps8 unconjugated
N° du produit ABIN967775
  • Antigène Voir toutes EPS8 Anticorps
    EPS8 (Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8))
    Épitope
    • 15
    • 9
    • 8
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 628-821
    Reactivité
    • 50
    • 23
    • 11
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Chien
    Hôte
    • 48
    • 3
    • 1
    Souris
    Clonalité
    • 51
    • 1
    Monoclonal
    Conjugué
    • 24
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp EPS8 est non-conjugé
    Application
    • 32
    • 22
    • 20
    • 13
    • 13
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Humain, Rat (Rattus), Chien
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse Eps8 aa. 628-821
    Clone
    15-Eps8
    Isotype
    IgG1
    Top Product
    Discover our top product EPS8 Anticorps primaire
  • Commentaires

    Related Products: ABIN967389, ABIN968550

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Burke, Schooler, Wiley: "Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking." dans: Molecular biology of the cell, Vol. 12, Issue 6, pp. 1897-910, (2001) (PubMed).

    Miyamoto, Teramoto, Gutkind, Yamada: "Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors." dans: The Journal of cell biology, Vol. 135, Issue 6 Pt 1, pp. 1633-42, (1997) (PubMed).

    Fazioli, Minichiello, Matoska, Castagnino, Miki, Wong, Di Fiore: "Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals." dans: The EMBO journal, Vol. 12, Issue 10, pp. 3799-808, (1993) (PubMed).

    Xie, Cho, Calaycay, Mumford, Swiderek, Lee, Ding, Troso, Nathan: "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages." dans: Science (New York, N.Y.), Vol. 256, Issue 5054, pp. 225-8, (1992) (PubMed).

  • Antigène
    EPS8 (Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8))
    Autre désignation
    Eps8 (EPS8 Produits)
    Synonymes
    anticorps AW261790, anticorps MGC81285, anticorps MGC146320, anticorps zgc:56041, anticorps epidermal growth factor receptor pathway substrate 8, anticorps epidermal growth factor receptor pathway substrate 8 L homeolog, anticorps EPS8, anticorps Eps8, anticorps eps8.L, anticorps eps8
    Sujet
    The p97 [Eps8] protein, a substrate for EGF-R tyrosine kinase, contains an SH3 domain, but lacks a functional SH2 domain. Antibodies to Eps8 recognize the 97 kDa protein and a less abundant 68 kDa protein. Both forms are tyrosine-phosphorylated following treatment of cells with EGF. It is likely that p68 [Eps8] is synthesized from an alternatively spliced mRNA since two major Eps8-specific mRNAs are detected by Northern analysis. Co-immunoprecipitation studies have demonstrated a physical association between the Eps8 protein and the EGF-R both in vivo and in vitro. For many EGF-R substrates, this interaction is mediated through an SH2 domain of the substrate. Since Eps8 lacks a well defined SH2 domain and a fusion protein containing the SH2-like region of Eps8 could not bind EGF-R, the mechanism of Eps8-EGF-R association remains unclear. Overexpression of Eps8 in fibroblasts and hematopoietic cells results in an increased mitogenic response to EGF, suggesting that Eps8 has a role in the modulation of EGF-R function.
    Poids moléculaire
    97 kDa
    Pathways
    EGFR Signaling Pathway, Regulation of Actin Filament Polymerization
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