CNTNAP1 anticorps (AA 1-1513)

N° du produit ABIN967781

Détail du produit anti-CNTNAP1 anticorps

Antigène: CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))

Épitope: AA 1-1513

Reactivité: Humain, Souris, Rat, Chien, Poulet, Grenouille

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CNTNAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Réactivité croisée: Chien, Rat (Rattus), Souris, Poulet, Grenouille

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human p190 aa. 1-1513

Clone: 30-p190

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-CNTNAP1 (ABIN967781)

Maddox, Burridge: "RhoA is required for cortical retraction and rigidity during mitotic cell rounding." dans: The Journal of cell biology, Vol. 160, Issue 2, pp. 255-65, (2003) (PubMed).

Wolf, Draghi, Liang, Dai, Uhrbom, Eklöf, Westermark, Holland, Resh: "p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3." dans: Genes & development, Vol. 17, Issue 4, pp. 476-87, (2003) (PubMed).

Brandt, Gimona, Hillmann, Haller, Mischak: "Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway." dans: The Journal of biological chemistry, Vol. 277, Issue 23, pp. 20903-10, (2002) (PubMed).

Nakahara, Mueller, Nomizu, Yamada, Yeh, Chen: "Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia." dans: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 9-12, (1998) (PubMed).

Settleman, Narasimhan, Foster, Weinberg: "Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus." dans: Cell, Vol. 69, Issue 3, pp. 539-49, (1992) (PubMed).

Détails sur CNTNAP1

Antigène: CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))

Autre désignation: p190 (CNTNAP1 Produits)

Synonymes: anticorps CNTNAP1, anticorps CASPR, anticorps CNTNAP, anticorps NRXN4, anticorps P190, anticorps Caspr, anticorps AI841080, anticorps NCP1, anticorps Nrxn4, anticorps p190, anticorps shm, anticorps contactin associated protein 1, anticorps contactin associated protein-like 1, anticorps CNTNAP1, anticorps cntnap1, anticorps Cntnap1

Sujet: GTPase activating proteins (GAPs) stimulate the GTP-hydrolyzing activity of GTPases, such as p21[ ras]. Ras-GAP (120kDa) is perhaps the best characterized GAP. p190 is a Ras-GAP associated protein that is tyrosine phosphorylated in transformed and growth factor-stimulated cells. Ras-GAP and p190 are targets of oncoproteins and growth factor receptors. Recombinant p190 enhances GTPase activity of the rho family of GTPases. The complete sequence of p190 exhibits three major regions: an N-terminal region with homology to all GTPases, a middle region homologous to transcriptional repressors, and a C-terminal region the is similar to n-chimerin and other small GTPases.

Poids moléculaire: 190 kDa

Pathways: Cell-Cell Junction Organization