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E-cadherin anticorps (C-Term)

CDH1 Reactivité: Humain, Souris, Rat, Chien WB, IHC, IF, IP Hôte: Souris Monoclonal 36-E unconjugated
N° du produit ABIN967800
  • Antigène Voir toutes E-cadherin (CDH1) Anticorps
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Épitope
    • 17
    • 17
    • 16
    • 16
    • 15
    • 15
    • 8
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 250
    • 102
    • 86
    • 18
    • 17
    • 15
    • 9
    • 9
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien
    Hôte
    • 202
    • 82
    • 8
    • 7
    Souris
    Clonalité
    • 188
    • 110
    • 1
    Monoclonal
    Conjugué
    • 140
    • 36
    • 29
    • 10
    • 10
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp E-cadherin est non-conjugé
    Application
    • 206
    • 94
    • 91
    • 68
    • 56
    • 55
    • 39
    • 35
    • 29
    • 27
    • 17
    • 16
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Chien, Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human E-Cadherin C-terminal Recombinant Protein
    Clone
    36-E
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product CDH1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Chua, Nivison-Smith, Fletcher, Trenholm, Awatramani, Kalloniatis: "Early remodeling of Müller cells in the rd/rd mouse model of retinal dystrophy." dans: The Journal of comparative neurology, Vol. 521, Issue 11, pp. 2439-53, (2014) (PubMed).

    Burns, Collado, Oliver, Corwin: "Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes." dans: The Journal of comparative neurology, Vol. 521, Issue 6, pp. 1430-48, (2013) (PubMed).

    Brusés: "N-cadherin regulates primary motor axon growth and branching during zebrafish embryonic development." dans: The Journal of comparative neurology, Vol. 519, Issue 9, pp. 1797-815, (2012) (PubMed).

    Akins, Benson, Greer: "Cadherin expression in the developing mouse olfactory system." dans: The Journal of comparative neurology, Vol. 501, Issue 4, pp. 483-97, (2007) (PubMed).

    Weng, Xin, Pablo, Grueneberg, Hagel, Bain, Müller, Papkoff: "Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein." dans: The Journal of biological chemistry, Vol. 277, Issue 21, pp. 18677-86, (2002) (PubMed).

    Miyoshi, Shillingford, Smith, Grimm, Wagner, Oka, Rosen, Robinson, Hennighausen: "Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium." dans: The Journal of cell biology, Vol. 155, Issue 4, pp. 531-42, (2001) (PubMed).

    Sheibani, Sorenson, Frazier: "Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases." dans: Molecular biology of the cell, Vol. 11, Issue 8, pp. 2793-802, (2000) (PubMed).

    Jaksits, Kriehuber, Charbonnier, Rappersberger, Stingl, Maurer: "CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 9, pp. 4869-77, (1999) (PubMed).

  • Antigène
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Autre désignation
    E-Cadherin (CDH1 Produits)
    Synonymes
    anticorps Arc-1, anticorps CD324, anticorps CDHE, anticorps ECAD, anticorps LCAM, anticorps UVO, anticorps E-cadherin, anticorps cdh1, anticorps si:dz180o5.2, anticorps uvo, anticorps lcam, anticorps E-Cad, anticorps XBcad, anticorps l-cam, anticorps xcdh1, anticorps cdhc-A, anticorps xb-cad, anticorps XTCAD-1, anticorps c-cadherin, anticorps cadherin-1, anticorps uvomorulin, anticorps XB-cadherin, anticorps arc-1, anticorps cd324, anticorps cdhe, anticorps ecad, anticorps AA960649, anticorps E-cad, anticorps Ecad, anticorps L-CAM, anticorps Um, anticorps cadherin 1, anticorps si:busm1-180o5.2, anticorps cadherin 1, type 1, E-cadherin (epithelial), anticorps cadherin 1, type 1 S homeolog, anticorps CDH1, anticorps si:busm1-180o5.2, anticorps cdh1, anticorps Cdh1, anticorps cdh1.S
    Sujet
    E-Cadherin is a 120-kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression. The 36/E-Cadherin monoclonal antibody recognizes the cytoplasmic domain of E-Cadherin, regardless of phosphorylation status. The peptide immunogen was generated from human E-Cadherin aa. 735-883.
    Synonyms: CD324, CDH1, CADH1, Cadherin-1, ECAD, CDHE, Arc-1, LCAM, UVO, Uvomorulin
    Poids moléculaire
    120 kDa
    Pathways
    Signalisation WNT, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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