STAT2 anticorps (AA 1-178)

N° du produit ABIN967806

Détail du produit anti-STAT2 anticorps

Antigène: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Épitope: AA 1-178

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STAT2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Stat2 aa. 1-178

Clone: 22-Stat2

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN968586, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-STAT2 (ABIN967806)

Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: "Regulation of STAT protein synthesis by c-Cbl." dans: Oncogene, Vol. 20, Issue 50, pp. 7326-33, (2001) (PubMed).

Russell-Harde, Wagner, Rani, Vogel, Colamonici, Ransohoff, Majchrzak, Fish, Perez, Croze: "Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling. Expression of IFNAR2c truncation mutants in U5A cells." dans: The Journal of biological chemistry, Vol. 275, Issue 31, pp. 23981-5, (2000) (PubMed).

Duff, Quinlan, Paxton, Naik, Caughman: "Pervanadate mimics IFNgamma-mediated induction of ICAM-1 expression via activation of STAT proteins." dans: The Journal of investigative dermatology, Vol. 108, Issue 3, pp. 295-301, (1997) (PubMed).

Ruff-Jamison, Chen, Cohen: "Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei." dans: Science (New York, N.Y.), Vol. 261, Issue 5129, pp. 1733-6, (1993) (PubMed).

Fu, Schindler, Improta, Aebersold, Darnell: "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7840-3, (1992) (PubMed).

Détails sur STAT2

Antigène: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Autre désignation: Stat2 (STAT2 Produits)

Synonymes: anticorps wu:fj84d07, anticorps p113, anticorps stat2, anticorps 1600010G07Rik, anticorps AW496480, anticorps ISGF-3, anticorps P113, anticorps STAT113, anticorps signal transducer and activator of transcription 2, anticorps AGAP000099-PA, anticorps stat2, anticorps STAT2, anticorps Stat2

Sujet: The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. These three polypeptides contain both SH2 and SH3 domains and have also been described as members of the ISGF3 (interferon-stimulated gene factor 3) complex. With the discovery of additional members of the Stat family (Stats3 & 4), the nomenclature has been revised to indicate the Stat family members in the order of their discovery. Stat 91, 84, and 113 have become Stat1alpha, Stat1beta, and Stat2, respectively. In response to IFN-alpha treatment, Stat1alpha, Stat1beta, and Stat2 become tyrosine-phosphorylated and migrate to the nucleus where they join a 48 kDa DNA binding protein and subsequently direct the transcription at IFN-alpha responsive elements. The genes encoding Stat2 and Stat1 are closely related. An extended acidic C-terminal region exclusive to Stat2 implicates a potential role in gene activation. Stat2 phosphorylation can occur independently of Stat1alpha, but phosphorylated Stat2 does appear to be dependent on its interaction with Stat1alpha for efficient nuclear localization and/or stability.

Poids moléculaire: 113 kDa

Pathways: Signalistation JAK/STAT, Hepatitis C, CXCR4-mediated Signaling Events