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PKC iota anticorps (AA 397-558)

PRKCI Reactivité: Humain, Souris, Rat, Chien, Poulet WB, IHC, IP, IF Hôte: Souris Monoclonal 41-PKClambda unconjugated
N° du produit ABIN967826
  • Antigène Voir toutes PKC iota (PRKCI) Anticorps
    PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))
    Épitope
    • 15
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 397-558
    Reactivité
    • 51
    • 38
    • 16
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Poulet
    Hôte
    • 44
    • 7
    Souris
    Clonalité
    • 44
    • 7
    Monoclonal
    Conjugué
    • 20
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PKC iota est non-conjugé
    Application
    • 43
    • 22
    • 18
    • 13
    • 13
    • 6
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
     Réactivité croisée
    Rat (Rattus), Chien, Souris, Poulet
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human PKClambda aa. 397-558
    Clone
    41-PKClambda
    Isotype
    IgG1
    Top Product
    Discover our top product PRKCI Anticorps primaire
  • Commentaires

    Related Products: ABIN967389, ABIN968545

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Trauzold, Wermann, Arlt, Schütze, Schäfer, Oestern, Röder, Ungefroren, Lampe, Heinrich, Walczak, Kalthoff: "CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells." dans: Oncogene, Vol. 20, Issue 31, pp. 4258-69, (2001) (PubMed).

    Pauken, Capco: "The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development." dans: Developmental biology, Vol. 223, Issue 2, pp. 411-21, (2000) (PubMed).

    Jain, Zhang, Kee, Li, Cao: "Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner." dans: The Journal of biological chemistry, Vol. 274, Issue 34, pp. 24392-400, (1999) (PubMed).

    Uberall, Giselbrecht, Hellbert, Fresser, Bauer, Gschwendt, Grunicke, Baier: "Conventional PKC-alpha, novel PKC-epsilon and PKC-theta, but not atypical PKC-lambda are MARCKS kinases in intact NIH 3T3 fibroblasts." dans: The Journal of biological chemistry, Vol. 272, Issue 7, pp. 4072-8, (1997) (PubMed).

    Akimoto, Mizuno, Osada, Hirai, Tanuma, Suzuki, Ohno: "A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells." dans: The Journal of biological chemistry, Vol. 269, Issue 17, pp. 12677-83, (1994) (PubMed).

  • Antigène
    PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))
    Autre désignation
    Protein Kinase C lambda (PRKCI Produits)
    Synonymes
    anticorps DXS1179E, anticorps PKCI, anticorps nPKC-iota, anticorps aPKC[l], anticorps hal, anticorps has, anticorps PRKCI, anticorps PKC, anticorps 2310021H13Rik, anticorps AI427505, anticorps PKClambda, anticorps Pkci, anticorps Pkcl, anticorps Prkcl, anticorps aPKClambda, anticorps mKIAA4165, anticorps protein kinase C iota, anticorps protein kinase C, iota, anticorps PRKCI, anticorps prkci, anticorps Prkci
    Sujet
    The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. These proteins are products of multiple genes and alternative splicing. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with the PKC activators Ca2+, phospholipid, diacylglycerol, or phorbol ester. However, the novel PKC (nPKC) subfamily members ( delta, epsilon, eta, and theta isoforms) and the atypical PKC (aPKC) subfamily members (zeta, ί, and lambda isoforms) are Ca2+ independent and lack the C2 domain. The aPKC members are unique in that their activity is independent of diacylglycerols and phorbol esters. They also lack one repeat of the cysteine-rich sequences that are conserved in cPKC and nPKC. The C-terminal region of PKC contains the catalytic domain. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters, and growth factors. PKClambda shows the highest degree of amino acid homology with PKCzeta (72%) and PKClambda mRNA is expressed in a variety of cells and tissues. The PKClambda protein kinase is capable of autophosphorylation and can be activated by phosphatidylserine, but not by other PKC activators such as diacylglycerols, Ca2+, or phorbol esters.
    Poids moléculaire
    74 kDa
    Pathways
    Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, Tube Formation
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