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RPS6KA1 anticorps (AA 1-184)

RPS6KA1 Reactivité: Humain, Souris, Rat, Chien, Poulet WB, IHC, IP, IF Hôte: Souris Monoclonal 78-RSK unconjugated
N° du produit ABIN967837
  • Antigène Voir toutes RPS6KA1 Anticorps
    RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))
    Épitope
    • 41
    • 30
    • 25
    • 18
    • 17
    • 16
    • 15
    • 8
    • 8
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-184
    Reactivité
    • 207
    • 124
    • 92
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Poulet
    Hôte
    • 216
    • 18
    Souris
    Clonalité
    • 193
    • 42
    Monoclonal
    Conjugué
    • 108
    • 17
    • 14
    • 11
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    Cet anticorp RPS6KA1 est non-conjugé
    Application
    • 186
    • 104
    • 54
    • 53
    • 51
    • 27
    • 26
    • 26
    • 15
    • 12
    • 9
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
     Réactivité croisée
    Chien, Rat (Rattus), Souris, Poulet
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human p90[rsk] aa. 1-184
    Clone
    78-RSK
    Isotype
    IgG2a
    Top Product
    Discover our top product RPS6KA1 Anticorps primaire
  • Commentaires

    Related Products: ABIN967389, ABIN968533

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Moor, Gan, Karmazyn, Fliegel: "Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium." dans: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16113-22, (2001) (PubMed).

    Morrione, Navarro, Romano, Dews, Reiss, Valentinis, Belletti, Baserga: "The role of the insulin receptor substrate-1 in the differentiation of rat hippocampal neuronal cells." dans: Oncogene, Vol. 20, Issue 35, pp. 4842-52, (2001) (PubMed).

    Majka, Janowska-Wieczorek, Ratajczak, Kowalska, Vilaire, Pan, Honczarenko, Marquez, Poncz, Ratajczak: "Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis." dans: Blood, Vol. 96, Issue 13, pp. 4142-51, (2000) (PubMed).

    Hsiao, Chou, Shih, Ferrell: "Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5480-4, (1994) (PubMed).

    Chung, Pelech, Blenis: "Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 11, pp. 4981-5, (1991) (PubMed).

  • Antigène
    RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))
    Autre désignation
    Rsk (RPS6KA1 Produits)
    Synonymes
    anticorps HU-1, anticorps MAPKAPK1A, anticorps RSK, anticorps RSK1, anticorps Rsk1, anticorps p90rsk, anticorps rsk, anticorps RPS6KA, anticorps hu-1, anticorps mapkapk1a, anticorps rsk1, anticorps wu:fc56h07, anticorps zgc:152654, anticorps ribosomal protein S6 kinase A1, anticorps ribosomal protein S6 kinase polypeptide 1, anticorps ribosomal protein S6 kinase A1-like, anticorps ribosomal protein S6 kinase A1 L homeolog, anticorps ribosomal protein S6 kinase a, polypeptide 1, anticorps RPS6KA1, anticorps Rps6ka1, anticorps RPS6KA1L, anticorps rps6ka1.L, anticorps rps6ka1
    Sujet
    The p90[rsk] (Rsk) and p70[s6k] kinases were first identified based on their ability to phosphorylate the 40S ribosomal protein S6 in vitro. Both of these enzymes are differentially regulated by serine/threonine phosphorylation in response to mitogenic stimulation. ERK1 and ERK2 have been shown to regulate Rsk activity. Once activated by this phosphorylation, a significant amount of Rsk can be found in the nucleus, suggesting that it has a role in nuclear signaling events. The regulation of nuclear Rsk and ERK activities by growth factors is coordinated with the induction of several early response genes. Rsk has also been shown to be activated by ionizing radiation, presumably through an activated MAP kinase. Studies in Xenopus oocytes and mouse NIH/3T3 cells indicate that inactive Rsk and ERK2 exist in a complex of approximately 110kDa. Upon phosphorylation of Rsk and ERK2, the heterodimer dissociates and at least a portion of these activated kinases translocate to the nucleus.
    Poids moléculaire
    90 kDa
    Pathways
    Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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