P-Cadherin anticorps (AA 72-259)

N° du produit ABIN967840

Détail du produit anti-P-Cadherin anticorps

Antigène: P-Cadherin (CDH3)

Épitope: AA 72-259

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp P-Cadherin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human P-Cadherin aa. 72-259

Clone: 56-P

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968533, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-P-Cadherin (ABIN967840)

Holsinger, Ward, Duffield, Zachwieja, Jallal: "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)." dans: Oncogene, Vol. 21, Issue 46, pp. 7067-76, (2002) (PubMed).

Bailey, Biddlestone, Shepherd, Barr, Warner, Jankowski: "Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasia-adenocarcinoma sequence: correlation with disease progression and dedifferentiation." dans: The American journal of pathology, Vol. 152, Issue 1, pp. 135-44, (1998) (PubMed).

Kantak, Kramer: "E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells." dans: The Journal of biological chemistry, Vol. 273, Issue 27, pp. 16953-61, (1998) (PubMed).

Tao, Edwards, Tubb, Wang, Bryan, McCrea: "beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex." dans: The Journal of cell biology, Vol. 134, Issue 5, pp. 1271-81, (1996) (PubMed).

Nose, Nagafuchi, Takeichi: "Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules." dans: The EMBO journal, Vol. 6, Issue 12, pp. 3655-61, (1988) (PubMed).

Détails sur P-Cadherin

Antigène: P-Cadherin (CDH3)

Autre désignation: P-Cadherin (CDH3 Produits)

Synonymes: anticorps CDH3, anticorps Cadherin-3, anticorps AI385538, anticorps Cadp, anticorps Cdhp, anticorps P-cadherin, anticorps Pcad, anticorps CDHP, anticorps HJMD, anticorps PCAD, anticorps E-Cad, anticorps E-cadherin, anticorps EP-cadherin, anticorps XTCAD-1, anticorps c-cadherin, anticorps cadherin-1, anticorps cdh1, anticorps cdh1-b, anticorps cdh3, anticorps cdhc-A, anticorps cdhp, anticorps hjmd, anticorps l-cam, anticorps lcam, anticorps pcad, anticorps uvo, anticorps uvomorulin, anticorps xb-cad, anticorps xcdh1, anticorps CDH15, anticorps K-CAM, anticorps cadherin 3, anticorps cadherin 3 L homeolog, anticorps Cadherin-3, anticorps CDH3, anticorps Cdh3, anticorps cdh3.L, anticorps cdh-3

Sujet: Cadherins are a family of transmembrane glycoproteins involved in the Ca2+-dependent cell-cell adhesion that occurs in many tissues. Cadherins are similar in their domain structure, Ca2+ and protease sensitivity, and molecular weight. However, these proteins have distinct tissue expression patterns and immunological reactivities. P-Cadherin is localized in placenta while E-Cadherin and N-Cadherin are found in epithelial and neural tissues, respectively. P-Cadherin is an 829 amino acid polypeptide with a putative signal peptide and precursor region, an extracellular domain containing several internal repeats, and a highly hydrophobic transmembrane region. The cytoplasmic domain provides a link to the cytoskeleton through the associated catenin proteins.

Poids moléculaire: 120 kDa