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JAK1 anticorps (AA 551-766)

JAK1 Reactivité: Humain, Souris, Rat, Poulet, Chien, Grenouille WB, IHC, IF, IP Hôte: Souris Monoclonal 73-JAK1 unconjugated
N° du produit ABIN967842
  • Antigène Voir toutes JAK1 Anticorps
    JAK1 (Janus Kinase 1 (JAK1))
    Épitope
    • 16
    • 16
    • 12
    • 10
    • 10
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 551-766
    Reactivité
    • 109
    • 83
    • 63
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Poulet, Chien, Grenouille
    Hôte
    • 88
    • 27
    • 1
    • 1
    Souris
    Clonalité
    • 82
    • 35
    Monoclonal
    Conjugué
    • 53
    • 8
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp JAK1 est non-conjugé
    Application
    • 76
    • 38
    • 27
    • 21
    • 17
    • 14
    • 12
    • 11
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Chien, Rat (Rattus), Souris, Poulet, Grenouille
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    5. For fluorochrome spectra and suitable instrument settings, please refer to us.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human JAK1 aa. 551-766
    Clone
    73-JAK1
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product JAK1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Kopantzev, Heller, Swaminathan, Rudikoff: "IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells." dans: Oncogene, Vol. 21, Issue 44, pp. 6791-800, (2002) (PubMed).

    Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: "Regulation of STAT protein synthesis by c-Cbl." dans: Oncogene, Vol. 20, Issue 50, pp. 7326-33, (2001) (PubMed).

    Kawazoe, Naka, Fujimoto, Kohzaki, Morita, Narazaki, Okumura, Saitoh, Nakagawa, Uchiyama, Akira, Kishimoto: "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation." dans: The Journal of experimental medicine, Vol. 193, Issue 2, pp. 263-9, (2001) (PubMed).

    Müller, Briscoe, Laxton, Guschin, Ziemiecki, Silvennoinen, Harpur, Barbieri, Witthuhn, Schindler: "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction." dans: Nature, Vol. 366, Issue 6451, pp. 129-35, (1993) (PubMed).

  • Antigène
    JAK1 (Janus Kinase 1 (JAK1))
    Autre désignation
    JAK1 (JAK1 Produits)
    Synonymes
    anticorps JAK1A, anticorps JAK1B, anticorps JTK3, anticorps AA960307, anticorps C130039L05Rik, anticorps wu:fb93e10, anticorps jak1, anticorps Janus kinase 1, anticorps tyrosine-protein kinase JAK1, anticorps JAK1, anticorps Jak1, anticorps jak1, anticorps LOC100286690
    Sujet
    The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130 kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-alpha and IFN-gamma. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-alpha or IFN-gamma. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-alpha and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-alpha or IFN-gamma, respectively.
    Poids moléculaire
    130 kDa
    Pathways
    Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response
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