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NOS1 anticorps (AA 1095-1289)

NOS1 Reactivité: Humain, Rat, Souris, Chien WB, IHC, IF, IP Hôte: Souris Monoclonal 16-nNOS-NOS Type I unconjugated
N° du produit ABIN967894
  • Antigène Voir toutes NOS1 Anticorps
    NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))
    Épitope
    • 27
    • 15
    • 12
    • 9
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1095-1289
    Reactivité
    • 128
    • 90
    • 63
    • 15
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Chien
    Hôte
    • 134
    • 21
    • 3
    Souris
    Clonalité
    • 128
    • 30
    Monoclonal
    Conjugué
    • 70
    • 20
    • 11
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NOS1 est non-conjugé
    Application
    • 118
    • 61
    • 48
    • 32
    • 28
    • 27
    • 26
    • 20
    • 19
    • 12
    • 8
    • 6
    • 5
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Rat (Rattus), Souris, Chien
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human nNOS aa. 1095-1289
    Clone
    16-nNOS-NOS Type I
    Isotype
    IgG2a
    Top Product
    Discover our top product NOS1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Noorian, Taylor, Annerino, Greene: "Neurochemical phenotypes of myenteric neurons in the rhesus monkey." dans: The Journal of comparative neurology, Vol. 519, Issue 17, pp. 3387-401, (2012) (PubMed).

    Schuh, Uldrijan, Telkamp, Rothlein, Neyses: "The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I." dans: The Journal of cell biology, Vol. 155, Issue 2, pp. 201-5, (2001) (PubMed).

    Sasaki, Gonzalez-Zulueta, Huang, Herring, Ahn, Ginty, Dawson, Dawson: "Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 15, pp. 8617-22, (2000) (PubMed).

    Yu, Shao, Qian, George, Rockey: "Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension." dans: The Journal of clinical investigation, Vol. 105, Issue 6, pp. 741-8, (2000) (PubMed).

    Nathan: "Nitric oxide as a secretory product of mammalian cells." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 6, Issue 12, pp. 3051-64, (1992) (PubMed).

  • Antigène
    NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))
    Autre désignation
    nNOS/NOS Type I (NOS1 Produits)
    Synonymes
    anticorps NOS1, anticorps IHPS1, anticorps N-NOS, anticorps NC-NOS, anticorps NOS, anticorps bNOS, anticorps nNOS, anticorps 2310005C01Rik, anticorps NO, anticorps NOS-I, anticorps Nos-1, anticorps nos, anticorps ihps1, anticorps nnos, anticorps nos1, anticorps nos1-A, anticorps nanos C2HC-type zinc finger 1, anticorps nitric oxide synthase 1, anticorps nitric oxide synthase 1, neuronal, anticorps nitric oxide synthase 1 (neuronal), anticorps nitric oxide synthase 1 L homeolog, anticorps NANOS1, anticorps NOS1, anticorps Nos1, anticorps nos1, anticorps nos1.L
    Sujet
    Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In neurons and endothelial cells, constitutive NOS (cNOS) is activated by agonists that increase intracellular Ca2+ levels and enhance calmodulin binding. Neuronal NOS (nNOS or bNOS) and endothelial NOS (ECNOS) have recognition sites for NADPH, FAD, FMN, and calmodulin and are regulated in a similar manner. However, both have been shown to be distinct gene products of about 155 kDa and 140 kDa, respectively, and the human forms show 52% amino acid identity. Neuronal NOS and induced macrophage NOS (iNOS) share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain. Neuronal NOS, a cytosolic protein present mainly in neural tissues, has been purified and characterized from rat cerebellum. The NO synthesized by this enzyme acts as a neurotransmitter. ECNOS has been cloned from human vascular endothelium as well as from bovine aortic endothelial cells (BAEC) and has a unique N-myristylation consensus sequence that may explain its membrane localization. This antibody is routinely tested by western blot analysis.
    Synonyms: NOS Type I, Neuronal Nitric Oxide Synthase
    Poids moléculaire
    155 kDa
    Pathways
    Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction
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