ITPR3 anticorps (AA 22-230)

N° du produit ABIN967898

Détail du produit anti-ITPR3 anticorps

Antigène: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Épitope: AA 22-230

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITPR3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Réactivité croisée: Boeuf (Vache), Chien, Souris, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human IP3R-3 aa. 22-230

Clone: 2-IP3R

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN968535, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-ITPR3 (ABIN967898)

Leite, Thrower, Echevarria, Koulen, Hirata, Bennett, Ehrlich, Nathanson: "Nuclear and cytosolic calcium are regulated independently." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2975-80, (2003) (PubMed).

Zanner, Hapfelmeier, Gratzl, Prinz: "Intracellular signal transduction during gastrin-induced histamine secretion in rat gastric ECL cells." dans: American journal of physiology. Cell physiology, Vol. 282, Issue 2, pp. C374-82, (2002) (PubMed).

Pin, Rukstalis, Johnson, Konieczny: "The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity." dans: The Journal of cell biology, Vol. 155, Issue 4, pp. 519-30, (2001) (PubMed).

Maranto: "Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium." dans: The Journal of biological chemistry, Vol. 269, Issue 2, pp. 1222-30, (1994) (PubMed).

Blondel, Takeda, Janssen, Seino, Bell: "Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues." dans: The Journal of biological chemistry, Vol. 268, Issue 15, pp. 11356-63, (1993) (PubMed).

Détails sur ITPR3

Antigène: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Autre désignation: IP 3R-3 (ITPR3 Produits)

Synonymes: anticorps Ip3r3, anticorps Itpr-3, anticorps IP3R, anticorps IP3R3, anticorps IP3R3X, anticorps inositol 1,4,5-triphosphate receptor 3, anticorps inositol 1,4,5-trisphosphate receptor type 3, anticorps inositol 1,4,5-trisphosphate receptor, type 3, anticorps Itpr3, anticorps ITPR3

Sujet: Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for many hormones, growth factors, and neurotransmitters. IP3 causes the release of Ca2+ from intracellular stores by binding specific receptors that are coupled to Ca2+ channels. A number of studies have identified a family of at least four IP3 receptors (IP3R). The type III receptor (IP3R-3) has been isolated and characterized in human and rat. IP3 receptors are commonly localized in the endoplasmic reticulum, but have also been identified in the nucleus and the plasma membrane. Co-expression of different IP3 receptors is detected in most tissues and cell lines. Although these receptors appear to have a similar specificity for inositol phosphates, the different receptors have been reported to have different affinities for IP3 as follows: type II > type I > type III. This antibody is routinely tested by western blot analysis.
Synonyms: Inositol 1,4,5-triphosphate receptor type III

Poids moléculaire: 300 kDa

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, BCR Signaling