Caspase 3 anticorps (AA 1-219)
-
- Antigène Voir toutes Caspase 3 (CASP3) Anticorps
- Caspase 3 (CASP3)
-
Épitope
- AA 1-219
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp Caspase 3 est non-conjugé
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Fluorescence Microscopy (FM)
- Attributs du produit
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human CPP32 aa. 1-219
- Clone
- 19-Caspase
- Isotype
- IgG2a
- Top Product
- Discover our top product CASP3 Anticorps primaire
-
-
- Commentaires
-
Related Products: ABIN968537, ABIN967389, ABIN967299
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20° C.
-
-
Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects." dans: The Journal of cell biology, Vol. 160, Issue 2, pp. 235-43, (2003) (PubMed).
: "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells." dans: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49504-10, (2002) (PubMed).
: "Immunohistochemical localization of caspase-3 correlates with clinical outcome in B-cell diffuse large-cell lymphoma." dans: Cancer research, Vol. 59, Issue 20, pp. 5386-91, (1999) (PubMed).
: "Two CD95 (APO-1/Fas) signaling pathways." dans: The EMBO journal, Vol. 17, Issue 6, pp. 1675-87, (1998) (PubMed).
: "
-
Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects." dans: The Journal of cell biology, Vol. 160, Issue 2, pp. 235-43, (2003) (PubMed).
-
- Antigène
- Caspase 3 (CASP3)
- Autre désignation
- Caspase-3 (CASP3 Produits)
- Synonymes
- anticorps CPP32, anticorps CPP32B, anticorps SCA-1, anticorps A830040C14Rik, anticorps AC-3, anticorps Apopain, anticorps CC3, anticorps Caspase-3, anticorps Lice, anticorps Yama, anticorps mldy, anticorps xcpp32, anticorps casp3, anticorps zgc:100890, anticorps CASP-3, anticorps caspase-3, anticorps caspase 3, anticorps caspase 3 S homeolog, anticorps caspase 3, apoptosis-related cysteine peptidase a, anticorps caspase 3, apoptosis-related cysteine peptidase, anticorps CASP3, anticorps Casp3, anticorps casp3.S, anticorps casp3a
- Sujet
-
Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic cells are characterized by loss of cell volume, plasma membrane blebbing, nuclear condensation, chromatin aggregation, and endonucleocytic degradation of DNA into nucleosomal fragments. Caspase-3 (CPP32, Yama, apopain) is a member of the family of cysteine proteases which includes interleukin-1beta converting enzyme (ICE) and C. elegans protein, Ced-3. An apoptotic signal such as granzyme B of cytotoxic T-cells (CTLs) or ICE-like proteases induces the intracellular cleavage of Caspase-3 from the inactive pro-form (32 kDa) to the active form which consists of the p20, p17, and p12 subunits. The active form of Caspase-3 cleaves several other apoptotic proteins including proteins such as DNA Fragmentation Factor (DFF). Apoptosis can be inhibited by coexpression of Bcl-2 as well as inhibitors of Caspase-3 or other members of the family of cysteine proteases. This antibody recognizes the human pro-form (inactive) of Caspase-3 at 32 kDa. In addition, it has been reported to recognize the active form of Caspase-3 at 20-21 kD in apoptotic cell lysates.
Synonyms: CPP32 - Poids moléculaire
- 32 kDa
- Pathways
- Apoptose, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
-