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NOS2 anticorps (AA 961-1144)

NOS2 Reactivité: Souris WB, IHC, IP, IF Hôte: Souris Monoclonal 6-iNOS-NOS Type II unconjugated
N° du produit ABIN967905
  • Antigène Voir toutes NOS2 Anticorps
    NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))
    Épitope
    • 16
    • 16
    • 12
    • 10
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 961-1144
    Reactivité
    • 110
    • 73
    • 69
    • 17
    • 2
    • 1
    Souris
    Hôte
    • 127
    • 14
    Souris
    Clonalité
    • 119
    • 22
    Monoclonal
    Conjugué
    • 73
    • 16
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp NOS2 est non-conjugé
    Application
    • 114
    • 45
    • 38
    • 32
    • 27
    • 27
    • 26
    • 18
    • 18
    • 17
    • 8
    • 4
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse iNOS aa. 961-1144
    Clone
    6-iNOS-NOS Type II
    Isotype
    IgG2a
    Top Product
    Discover our top product NOS2 Anticorps primaire
  • Commentaires

    Related Products: ABIN968550, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Heneka, Klockgether, Feinstein: "Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 18, pp. 6862-7, (2000) (PubMed).

    Marrogi, Pass, Khan, Metheny-Barlow, Harris, Gerwin: "Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor." dans: Cancer research, Vol. 60, Issue 14, pp. 3696-700, (2000) (PubMed).

    Miles, Bowman, Rao, Baatz, Huffman: "Pulmonary surfactant inhibits LPS-induced nitric oxide production by alveolar macrophages." dans: The American journal of physiology, Vol. 276, Issue 1 Pt 1, pp. L186-96, (1999) (PubMed).

    Sciorati, Rovere, Ferrarini, Heltai, Manfredi, Clementi: "Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes." dans: The Journal of biological chemistry, Vol. 272, Issue 37, pp. 23211-5, (1997) (PubMed).

    Xie, Cho, Calaycay, Mumford, Swiderek, Lee, Ding, Troso, Nathan: "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages." dans: Science (New York, N.Y.), Vol. 256, Issue 5054, pp. 225-8, (1992) (PubMed).

  • Antigène
    NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))
    Autre désignation
    iNOS/NOS Type II (NOS2 Produits)
    Synonymes
    anticorps HEP-NOS, anticorps INOS, anticorps NOS, anticorps NOS2A, anticorps NOS-II, anticorps Nos-2, anticorps Nos2a, anticorps i-NOS, anticorps iNOS, anticorps iNos, anticorps NOS2a, anticorps NOS2, anticorps BmNOS2, anticorps Nsl, anticorps nos2, anticorps nitric oxide synthase 2, anticorps nitric oxide synthase 2, inducible, anticorps inducible nitric oxide synthase, anticorps inducible nitric-oxide synthase, anticorps nanos C2HC-type zinc finger 2, anticorps NOS2, anticorps Nos2, anticorps nos2, anticorps LOC396821, anticorps NANOS2
    Sujet
    Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In macrophages and other cell types, NOS (iNOS or macNOS) activity increases following exposure to cytokines (IFN-gamma, TNF-alpha, and IL-1) and microbial products (lipopolysaccharide (LPS)), iNOS is activated independently of Ca2+/calmodulin and its level of expression is tightly controlled by several transcription factors, including NFkappaB. Data indicates that TGF-beta affects translation of iNOS mRNA and decreases iNOS protein stability. Normally undetectable in brain tissue, iNOS mRNA has been observed in CNS tissues of animals under experimental pathologic conditions. iNOS and nNOS share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain.
    Poids moléculaire
    130 kDa
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Inositol Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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