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RAN anticorps (AA 7-171)

RAN Reactivité: Humain, Souris, Rat, Chien, Poulet WB, IHC, IF, IP Hôte: Souris Monoclonal 20-Ran unconjugated
N° du produit ABIN967913
  • Antigène Voir toutes RAN Anticorps
    RAN (RAN, Member RAS Oncogene Family (RAN))
    Épitope
    • 15
    • 15
    • 8
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 7-171
    Reactivité
    • 89
    • 45
    • 43
    • 7
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chien, Poulet
    Hôte
    • 81
    • 6
    • 2
    Souris
    Clonalité
    • 82
    • 6
    Monoclonal
    Conjugué
    • 44
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp RAN est non-conjugé
    Application
    • 66
    • 34
    • 29
    • 26
    • 26
    • 17
    • 11
    • 11
    • 9
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Poulet, Chien, Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Ran aa. 7-171
    Clone
    20-Ran
    Isotype
    IgG2a
    Top Product
    Discover our top product RAN Anticorps primaire
  • Commentaires

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Nemergut, Lindsay, Brownawell, Macara: "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor." dans: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 17385-8, (2002) (PubMed).

    Schwoebel, Ho, Moore: "The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion." dans: The Journal of cell biology, Vol. 157, Issue 6, pp. 963-74, (2002) (PubMed).

    Faleiro, Lazebnik: "Caspases disrupt the nuclear-cytoplasmic barrier." dans: The Journal of cell biology, Vol. 151, Issue 5, pp. 951-9, (2000) (PubMed).

    Iborra, Jackson, Cook: "The path of RNA through nuclear pores: apparent entry from the sides into specialized pores." dans: Journal of cell science, Vol. 113 Pt 2, pp. 291-302, (2000) (PubMed).

    Drivas, Shih, Coutavas, Rush, DEustachio: "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line." dans: Molecular and cellular biology, Vol. 10, Issue 4, pp. 1793-8, (1990) (PubMed).

  • Antigène
    RAN (RAN, Member RAS Oncogene Family (RAN))
    Autre désignation
    Ran (RAN Produits)
    Synonymes
    anticorps ARA24, anticorps Gsp1, anticorps TC4, anticorps ran, anticorps ara24, anticorps gsp1, anticorps ran-1, anticorps tc4, anticorps RAN, anticorps RANP1, anticorps AAF30287, anticorps CG1404, anticorps Dmel\CG1404, anticorps Ran, anticorps dran, anticorps l(1)G0075, anticorps ran10A, anticorps fc16b04, anticorps wu:fc16b04, anticorps RAN, member RAS oncogene family, anticorps RAN, member RAS oncogene family S homeolog, anticorps CG1404 gene product from transcript CG1404-RC, anticorps RAN, anticorps Ran, anticorps ran.S, anticorps ran
    Sujet
    Ran is a highly conserved GTPase that is ubiquitously expressed. At steady-state, 80-90% of cellular Ran is located in the nucleus, with the remainder in the cytoplasm. The human TC4/Ran cDNA was originally isolated based on the predicted homology of its encoded protein product to Ras. Unlike other members of the Ras superfamily, Ran does not appear to contain signals for lipid modification, nor does it appear to show membrane localization. Ran has been implicated in a number of cellular processes such as the initiation of DNA replication, entry into and exit from mitosis and in nuclear RNA and protein transport through the nuclear pore complex. A number of Ran binding proteins have been identified. One of the smaller proteins identified is a 28kDa cytosolic molecule known as RanBP1. The GTP-bound state of Ran is stabilized through its binding to RanBP1.
    Poids moléculaire
    25 kDa
    Pathways
    Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
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