gamma 1 Adaptin anticorps (AA 642-821)

N° du produit ABIN967934

Détail du produit anti-gamma 1 Adaptin anticorps

Antigène: gamma 1 Adaptin (AP1G1) (Adaptor-Related Protein Complex 1, gamma 1 Subunit (AP1G1))

Épitope: AA 642-821

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp gamma 1 Adaptin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Rat (Rattus), Humain, Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse Adaptin gamma aa. 642-821

Clone: 88-Adaptin gamma

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968539, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-gamma 1 Adaptin (ABIN967934)

Nagahama, Suzuki, Hamada, Hatsuzawa, Tani, Yamamoto, Tagaya: "SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation." dans: Molecular biology of the cell, Vol. 14, Issue 1, pp. 262-73, (2003) (PubMed).

Eskelinen, Illert, Tanaka, Schwarzmann, Blanz, Von Figura, Saftig: "Role of LAMP-2 in lysosome biogenesis and autophagy." dans: Molecular biology of the cell, Vol. 13, Issue 9, pp. 3355-68, (2002) (PubMed).

Kalthoff, Groos, Kohl, Mahrhold, Ungewickell: "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi." dans: Molecular biology of the cell, Vol. 13, Issue 11, pp. 4060-73, (2002) (PubMed).

Wasiak, Legendre-Guillemin, Puertollano, Blondeau, Girard, de Heuvel, Boismenu, Bell, Bonifacino, McPherson: "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics." dans: The Journal of cell biology, Vol. 158, Issue 5, pp. 855-62, (2002) (PubMed).

Robinson: "Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus." dans: The Journal of cell biology, Vol. 111, Issue 6 Pt 1, pp. 2319-26, (1991) (PubMed).

Détails sur gamma 1 Adaptin

Antigène: gamma 1 Adaptin (AP1G1) (Adaptor-Related Protein Complex 1, gamma 1 Subunit (AP1G1))

Autre désignation: Adaptin gamma (AP1G1 Produits)

Synonymes: anticorps ADTG, anticorps CLAPG1, anticorps AA409002, anticorps AU041323, anticorps AW551707, anticorps Adtg, anticorps D8Ertd374e, anticorps adtg, anticorps wu:fc30a11, anticorps zgc:56079, anticorps AP1G1, anticorps adaptor related protein complex 1 gamma 1 subunit, anticorps AP-1 complex subunit gamma-1, anticorps AP-1 adaptor complex gamma subunit Apl4, anticorps hypothetical protein, anticorps adaptor protein complex AP-1, gamma 1 subunit, anticorps adaptor-related protein complex 1, gamma 1 subunit, anticorps adaptor related protein complex 1 gamma 1 subunit L homeolog, anticorps gamma-adaptin, anticorps AP1G1, anticorps NCU04121, anticorps PTRG_00081, anticorps SJAG_01809, anticorps UREG_02085, anticorps BDBG_07402, anticorps PAAG_11376, anticorps MCYG_00840, anticorps PITG_11143, anticorps VDBG_09354, anticorps Ap1g1, anticorps ap1g1, anticorps ap1g1.L, anticorps ANI_1_330014, anticorps AOR_1_802184, anticorps MGYG_01130, anticorps EDI_324200, anticorps TERG_00390, anticorps Tsp_09544

Sujet: Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins (gamma, alpha, delta, or epsilon and beta1, beta2, beta3, or beta4, respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, or µ4) and one small chain ( sigma1, sigma2, sigma3, or sigma4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. Adaptin gamma shows more homology with Adaptin alpha than with Adaptin beta. The conserved regions between Adaptins gamma and alpha could be important for binding to other components of the AP-1 and AP-2 complexes, respectively.

Poids moléculaire: 104 kDa