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Synaptotagmin anticorps (AA 72-223)

SYT Reactivité: Rat WB Hôte: Souris Monoclonal BC17 unconjugated
N° du produit ABIN967965
  • Antigène Voir toutes Synaptotagmin (SYT) Anticorps
    Synaptotagmin (SYT)
    Épitope
    • 15
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 72-223
    Reactivité
    • 38
    • 37
    • 21
    • 2
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 35
    • 3
    Souris
    Clonalité
    • 35
    • 3
    Monoclonal
    Conjugué
    • 17
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Synaptotagmin est non-conjugé
    Application
    • 30
    • 13
    • 13
    • 12
    • 11
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB)
     Réactivité croisée
    Humain
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    Purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Rat Synaptotagmin
    Clone
    BC17
    Isotype
    IgG1
    Top Product
    Discover our top product SYT Anticorps primaire
  • Commentaires

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 µg/ml
    Buffer
    Aqueous buffered solution containing BSA, glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Liu, Fallon, Lashuel, Liu, Lansbury: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." dans: Cell, Vol. 111, Issue 2, pp. 209-18, (2002) (PubMed).

    Ramalho-Santos, Moreno, Sutovsky, Chan, Hewitson, Wessel, Simerly, Schatten: "SNAREs in mammalian sperm: possible implications for fertilization." dans: Developmental biology, Vol. 223, Issue 1, pp. 54-69, (2000) (PubMed).

    Duncan, Don-Wauchope, Tapechum, Shipston, Chow, Estibeiro: "High-efficiency Semliki Forest virus-mediated transduction in bovine adrenal chromaffin cells." dans: The Biochemical journal, Vol. 342 Pt 3, pp. 497-501, (1999) (PubMed).

    Scheller: "Membrane trafficking in the presynaptic nerve terminal." dans: Neuron, Vol. 14, Issue 5, pp. 893-7, (1995) (PubMed).

    Perin, Johnston, Ozcelik, Jahn, Francke, Südhof: "Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans." dans: The Journal of biological chemistry, Vol. 266, Issue 1, pp. 615-22, (1991) (PubMed).

  • Antigène
    Synaptotagmin (SYT)
    Autre désignation
    Synaptotagmin (SYT Produits)
    Synonymes
    anticorps Syti, anticorps GB20036, anticorps DKFZP459P193, anticorps SYT1, anticorps SytI, anticorps SyNapTotagmin, anticorps synaptotagmin, anticorps synaptotagmin 1, anticorps snt-5, anticorps snt-6, anticorps snt-3, anticorps Syt, anticorps Syt1, anticorps SYT1
    Sujet
    Synaptotagmin (p65) is an abundant synaptic vesicle protein that contains a single transmembrane region and two copies of an internal repeat that is homologous to the regulatory region of Protein Kinase C. It appears that synaptotagmin has a regulatory role in the synaptic vesicle pathway, particularly in vesicle docking and/or fusion with the plasmalemma. A model has been proposed to explain docking, activation, and fusion of synaptic vesicles with donor membranes. This model suggests that VAMP/synaptobrevin and synaptotagmin (vSNARE) on the synaptic vesicle, and SNAP-25 and syntaxin (tSNAREs) on the plasma membrane, interact to form a 7S complex. Two additional soluble proteins, alphaSNAP and NSF, are later added to the 7S complex, accompanied by the loss of synaptotagmin. The resulting 20S complex contains syntaxin, SNAP-25, VAMP, alphaSNAP, and NSF. Genetic studies in several species demonstrate that mutation or deletion of synaptotagmin results in a large decrease in Ca2+ triggered transmitter release. Mammalian synapses that lack synaptotagmin show a selective decrease in a fast component of release, suggesting that synaptotagmin is the Ca2+ sensor triggering exocytosis.
    Poids moléculaire
    65 kDa
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