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RIPK1 anticorps (AA 385-650)

RIPK1 Reactivité: Humain, Souris, Rat, Chien, Poulet WB, IHC, IP, IF Hôte: Souris Monoclonal 38-RIP unconjugated
N° du produit ABIN967984
  • Antigène Voir toutes RIPK1 Anticorps
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Épitope
    • 16
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 385-650
    Reactivité
    • 90
    • 40
    • 29
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Poulet
    Hôte
    • 84
    • 13
    Souris
    Clonalité
    • 75
    • 22
    Monoclonal
    Conjugué
    • 41
    • 9
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RIPK1 est non-conjugé
    Application
    • 66
    • 33
    • 21
    • 15
    • 14
    • 13
    • 13
    • 12
    • 6
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
     Réactivité croisée
    Souris, Rat (Rattus), Chien, Poulet
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human RIP aa. 385-650
    Clone
    38-RIP
    Isotype
    IgG2a
    Top Product
    Discover our top product RIPK1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968536, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Devin, Lin, Yamaoka, Li, Karin, Liu Zg: "The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF." dans: Molecular and cellular biology, Vol. 21, Issue 12, pp. 3986-94, (2001) (PubMed).

    Fulda, Meyer, Debatin: "Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression." dans: Cancer research, Vol. 60, Issue 14, pp. 3947-56, (2000) (PubMed).

    Lewis, Devin, Miller, Lin, Rodriguez, Neckers, Liu: "Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation." dans: The Journal of biological chemistry, Vol. 275, Issue 14, pp. 10519-26, (2000) (PubMed).

    Stanger, Leder, Lee, Kim, Seed: "RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death." dans: Cell, Vol. 81, Issue 4, pp. 513-23, (1995) (PubMed).

  • Antigène
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Autre désignation
    RIP (RIPK1 Produits)
    Synonymes
    anticorps RIP, anticorps RIP1, anticorps D330015H01Rik, anticorps Rinp, anticorps Rip1, anticorps rip1, anticorps ripk1, anticorps xRIP1beta, anticorps xrip1, anticorps receptor interacting serine/threonine kinase 1, anticorps receptor (TNFRSF)-interacting serine-threonine kinase 1, anticorps receptor interacting serine/threonine kinase 1 L homeolog, anticorps RIPK1, anticorps Ripk1, anticorps ripk1.L
    Sujet
    Binding or cross linking of the Fas antigen (also known as APO-1 and CD95) is known to elicit apoptosis in susceptible cells. Fas is a member of a family of cell surface receptors which includes tumor necrosis factor receptors (TNF-R, and TNF-R2) and nerve growth factor receptors (NGF-R), CD40, OX40, CD30, CD27, and 4-1BB. Several members of this family have been shown to regulate or induce cell death (TNF-R1 and TNF-R2). A 74 kDa member of this family protein named RIP (Receptor Interacting Protein) contains an N-terminal region with homology to protein kinases and a C-terminal region containing a cytoplasmic death domain present in both Fas and TNF-R1. Both Fas and RIP have been shown to require this death domain to induce apoptosis and overexpression of RIP has been shown to induce cell death in transfected cells.
    Synonyms: Receptor Interacting Protein
    Poids moléculaire
    74 kDa
    Pathways
    Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway
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