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DAB2 anticorps (AA 31-45)

DAB2 Reactivité: Humain, Souris, Rat WB, IHC, IF, IP Hôte: Souris Monoclonal 52-p96 unconjugated
N° du produit ABIN967989
  • Antigène Voir toutes DAB2 Anticorps
    DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
    Épitope
    • 16
    • 15
    • 13
    • 13
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 31-45
    Reactivité
    • 49
    • 34
    • 21
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 63
    • 13
    • 1
    Souris
    Clonalité
    • 66
    • 11
    Monoclonal
    Conjugué
    • 21
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp DAB2 est non-conjugé
    Application
    • 68
    • 33
    • 26
    • 26
    • 18
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Humain, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse p96 aa. 31-45
    Clone
    52-p96
    Isotype
    IgG1
    Top Product
    Discover our top product DAB2 Anticorps primaire
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • Mishra, Keyel, Hawryluk, Agostinelli, Watkins, Traub: "Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor." dans: The EMBO journal, Vol. 21, Issue 18, pp. 4915-26, (2002) (PubMed).

    Hocevar, Smine, Xu, Howe: "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway." dans: The EMBO journal, Vol. 20, Issue 11, pp. 2789-801, (2001) (PubMed).

    Smith, Capo-chichi, He, Smedberg, Yang, Prowse, Godwin, Hamilton, Xu: "Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells." dans: The Journal of biological chemistry, Vol. 276, Issue 50, pp. 47303-10, (2001) (PubMed).

    Xu, Yang, Jackowski, Rock: "Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product." dans: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14184-91, (1995) (PubMed).

  • Antigène
    DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
    Autre désignation
    p96 (DAB2 Produits)
    Synonymes
    anticorps DOC-2, anticorps DOC2, anticorps 5730435J12Rik, anticorps AA960054, anticorps AI957090, anticorps D15Wsu122e, anticorps D630005B22Rik, anticorps Doc-2, anticorps Doc2, anticorps p96, anticorps DAB2, clathrin adaptor protein, anticorps disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila), anticorps Dab, mitogen-responsive phosphoprotein, homolog 2, anticorps disabled 2, mitogen-responsive phosphoprotein, anticorps DAB2, anticorps dab2, anticorps Dab2
    Sujet
    CSF-1 is a growth factor that stimulates the growth and differentiation of immature lymphocytes and is required for the survival of mononuclear phagocytes. Binding of CSF-1 induces dimerization and autophosphorylation of its receptor. This results in the activation of several signal transduction pathways. A unique 96 kDa protein is a component in the CSF-1 signal transduction cascade. p96 is phosphorylated on serine following mitogenic stimulation of a mouse macrophage cell line. p96 contains three potential C-terminal ERK kinase phosphorylation sites, as well as several proline-rich sequences that are potential binding sites for SH3-containing proteins. Structural similarities have been found between p96 and Dab, a product of the Drosophila disabled gene, and p96 was also identified as Disabled-2 (Dab-2) and as differentially expressed in ovarian carcinoma-2 (DOC-2) . Dab-2/p96 has been shown to be essential for TGFbeta signaling by facilitating signal transduction from the TGFbeta receptor to the Smad family of transcription factors. Thus, Dab-2/p96 is an important adaptor molecule in growth factor signaling pathways.
    Synonyms: Disabled-2
    Poids moléculaire
    96 kDa
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
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