KPNA2 anticorps (AA 254-497)

N° du produit ABIN967998

Détail du produit anti-KPNA2 anticorps

Antigène: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Épitope: AA 254-497

Reactivité: Humain, Souris, Rat, Chien, Blow Fly

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KPNA2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Souris, Rat (Rattus), Chien, Mouche des fruits (Drosophila melanogaster)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Rch-1 aa. 254-497

Clone: 2-Karyopherin alpha

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968535, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-KPNA2 (ABIN967998)

Grozinger, Schreiber: "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 14, pp. 7835-40, (2000) (PubMed).

Moroianu, Hijikata, Blobel, Radu: "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 14, pp. 6532-6, (1995) (PubMed).

Weis, Mattaj, Lamond: "Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences." dans: Science (New York, N.Y.), Vol. 268, Issue 5213, pp. 1049-53, (1995) (PubMed).

Détails sur KPNA2

Antigène: KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Autre désignation: Karyopherin alpha 2 (KPNA2 Produits)

Synonymes: anticorps IPOA1, anticorps QIP2, anticorps RCH1, anticorps SRP1alpha, anticorps ima2, anticorps importin, anticorps 2410044B12Rik, anticorps PTAC58, anticorps Rch1, anticorps ipoa1, anticorps kpna2, anticorps qip2, anticorps rch1, anticorps srp1alpha, anticorps hm:zeh0389, anticorps hm:zeh0389r, anticorps zgc:113902, anticorps zgc:86945, anticorps karyopherin subunit alpha 2, anticorps importin subunit alpha-2, anticorps Importin subunit alpha-2, anticorps karyopherin (importin) alpha 2, anticorps karyopherin alpha-2 subunit like L homeolog, anticorps karyopherin alpha 2 (RAG cohort 1, importin alpha 1), anticorps KPNA2, anticorps EDI_246290, anticorps EDI_335040, anticorps ima2, anticorps Kpna2, anticorps kpna2.L, anticorps kpna2

Sujet: The two step process of importing proteins into the nucleus involves the binding and interaction of several cytosolic and nuclear pore proteins. Proteins to be translocated into the nucleus contain a nuclear localization sequence (NLS) which is recognized and bound by carrier proteins in the cytosol. Heterodimers belonging to a highly conserved family of proteins called karyopherins are required for successful nuclear localization of cytosolic proteins. The alpha-subunits appear to function in the binding of NLS (both simple and bitartite NLS motifs), but both alpha- and beta-subunits are required for successful docking to the nuclear envelope. ATP is required for complete translocation of proteins into the nucleus. Karyopherin alpha2 was first identified as Rch-1, an NLS receptor which interacts with the RAG-1 recombination-activating protein in developing B and T cells. Rch-1 has been reported to be 44% identical to karyopherin alpha1 (hSRP-1 /NPI-1). This antibody is routinely tested by western blot analysis.
Synonyms: Rch-1

Poids moléculaire: 58 kDa

Pathways: M Phase, Protein targeting to Nucleus