Caveolin-1 anticorps (AA 1-178)

N° du produit ABIN968000

Détail du produit anti-Caveolin-1 anticorps

Antigène: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Épitope: AA 1-178

Reactivité: Humain, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caveolin-1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: RSV-CEF Caveolin aa. 1-178

Clone: 2234-Caveolin 1

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968554

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-Caveolin-1 (ABIN968000)

Oh, Schnitzer: "Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default." dans: Molecular biology of the cell, Vol. 12, Issue 3, pp. 685-98, (2001) (PubMed).

Razani, Zhang, Bitzer, von Gersdorff, Böttinger, Lisanti: "Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor." dans: The Journal of biological chemistry, Vol. 276, Issue 9, pp. 6727-38, (2001) (PubMed).

Schlegel, Arvan, Lisanti: "Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum." dans: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 4398-408, (2001) (PubMed).

Conrad, Smart, Ying, Anderson, Bloom: "Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps." dans: The Journal of cell biology, Vol. 131, Issue 6 Pt 1, pp. 1421-33, (1996) (PubMed).

Scherer, Tang, Chun, Sargiacomo, Lodish, Lisanti: "Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe." dans: The Journal of biological chemistry, Vol. 270, Issue 27, pp. 16395-401, (1995) (PubMed).

Détails sur Caveolin-1

Antigène: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Autre désignation: Caveolin 1 (CAV1 Produits)

Synonymes: anticorps fc07c04, anticorps wu:fc07c04, anticorps Cav-1, anticorps bscl3, anticorps cav1, anticorps cav1a, anticorps cgl3, anticorps vip21, anticorps cav1b, anticorps caveolin-1, anticorps cav, anticorps mstp085, anticorps Caveolin-1, anticorps CAV1, anticorps cav-1, anticorps Cav, anticorps caveolin 1, anticorps BSCL3, anticorps CGL3, anticorps MSTP085, anticorps PPH3, anticorps VIP21, anticorps caveolin 1, anticorps caveolin 1 L homeolog, anticorps caveolin 1 S homeolog, anticorps caveolin 1, caveolae protein, anticorps caveolin 1, caveolae protein, 22kDa, anticorps Caveolin, anticorps cav1, anticorps cav1.L, anticorps cav1.S, anticorps CAV1, anticorps Cav1, anticorps cav-1

Sujet: Identified as a tyrosine phosphorylated protein in Rous sarcoma virus-transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Caveolin-1 can generate two forms, alpha and beta, due to alternate splicing of the mRNA. Caveolin-1 forms large lipid-binding homo-oligomers which are believed to play a role in caveolae formation. It may also function as a scaffolding protein which concentrates and organizes signaling molecules, a role supported by the fact that caveolin-1 interacts directly with inactive Ras and G-protein alpha subunits. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 22 kDa

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals