ANKS1B anticorps (AA 107-268)

N° du produit ABIN968021

Détail du produit anti-ANKS1B anticorps

Antigène: ANKS1B (Ankyrin Repeat and Sterile alpha Motif Domain Containing 1B (ANKS1B))

Épitope: AA 107-268

Reactivité: Humain, Souris, Rat, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ANKS1B est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Réactivité croisée: Poulet, Souris, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human EB1 aa. 107-268

Clone: 5-EB1

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-ANKS1B (ABIN968021)

Etienne-Manneville, Hall: "Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity." dans: Nature, Vol. 421, Issue 6924, pp. 753-6, (2003) (PubMed).

Askham, Vaughan, Goodson, Morrison: "Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome." dans: Molecular biology of the cell, Vol. 13, Issue 10, pp. 3627-45, (2002) (PubMed).

Komarova, Akhmanova, Kojima, Galjart, Borisy: "Cytoplasmic linker proteins promote microtubule rescue in vivo." dans: The Journal of cell biology, Vol. 159, Issue 4, pp. 589-99, (2002) (PubMed).

Mamane, Grandvaux, Hernandez, Sharma, Innocente, Lee, Azimi, Lin, Hiscott: "Repression of IRF-4 target genes in human T cell leukemia virus-1 infection." dans: Oncogene, Vol. 21, Issue 44, pp. 6751-65, (2002) (PubMed).

Su, Huang, Fair, Powell, Heston: "Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression." dans: Cancer research, Vol. 55, Issue 7, pp. 1441-3, (1995) (PubMed).

Détails sur ANKS1B

Antigène: ANKS1B (Ankyrin Repeat and Sterile alpha Motif Domain Containing 1B (ANKS1B))

Autre désignation: EB1 (ANKS1B Produits)

Synonymes: anticorps AIDA, anticorps AIDA-1, anticorps ANKS2, anticorps EB-1, anticorps EB1, anticorps cajalin-2, anticorps AIDA-1b, anticorps C030032C09Rik, anticorps E530015N03Rik, anticorps ENSMUSG00000078431, anticorps Gm10937, anticorps Gm1555, anticorps RGD1565556, anticorps si:ch211-146a9.3, anticorps si:dkey-11k24.3, anticorps Anks1b, anticorps ankyrin repeat and sterile alpha motif domain containing 1B, anticorps ankyrin repeat and sterile alpha motif domain-containing protein 1B, anticorps ANKS1B, anticorps Anks1b, anticorps anks1b, anticorps LOC100717398

Sujet: Familial adenomatous polyposis is an autosomal inherited disease characterized by mutations in the APC (adenomatous polyposis coli) gene. Individuals with this disease are predisposed to colorectal polyps and cancer. It has been proposed that disruption of the APC gene plays a role in the disease. APC is a large coiled-coil protein that interacts, via its carboxy terminus, with catenins and with the protein, EB1. This 30 kDa protein was discovered as a result of its strong binding to the C-terminal domain of APC. Like the APC-binding proteins beta-Catenin and pp120Cas, EB1 may play an essential role in modulating APC activity and tumorigenesis. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 30 kDa