HCLS1 anticorps (AA 17-190)

N° du produit ABIN968027

Détail du produit anti-HCLS1 anticorps

Antigène: HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))

Épitope: AA 17-190

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HCLS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human HS1 aa. 17-190

Clone: 9-HS1

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-HCLS1 (ABIN968027)

Fukuda, Kitamura, Taniuchi, Maekawa, Benhamou, Sarthou, Watanabe: "Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 16, pp. 7302-6, (1995) (PubMed).

Takemoto, Furuta, Li, Strong-Sparks, Hashimoto: "LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck." dans: The EMBO journal, Vol. 14, Issue 14, pp. 3403-14, (1995) (PubMed).

Yamanashi, Okada, Semba, Yamori, Umemori, Tsunasawa, Toyoshima, Kitamura, Watanabe, Yamamoto: "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3631-5, (1993) (PubMed).

Détails sur HCLS1

Antigène: HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))

Autre désignation: HS1 (HCLS1 Produits)

Synonymes: anticorps CTTNL, anticorps HS1, anticorps AW213261, anticorps HCLS1, anticorps hcls1, anticorps si:dkey-9a20.6, anticorps wu:fk96b08, anticorps zgc:154014, anticorps hematopoietic cell-specific Lyn substrate 1, anticorps hematopoietic cell specific Lyn substrate 1, anticorps hematopoietic lineage cell-specific protein-like, anticorps HCLS1, anticorps Hcls1, anticorps LOC100223649, anticorps hcls1

Sujet: HS1 (lck-binding protein 1 (lckBP1)) is a protein of 486 amino acids with homology to cytoplasmic tyrosine kinases. The protein contains an SH3 domain and two proline-rich regions, that may be the binding site for lck. Co- mmunoprecipitation experiments demonstrated a tight association between HS1 and lck. The SH3 domain of lck is necessary for this interaction. In addition, HS1 contains tandem repeat sequence of seven amino acids which is a substrate for the tyrosine kinase src. This sequence is also found in the protein cortactin. Therefore, HS1, like cortactin, may be an important adaptor that is critical for the regulation of cellular tyrosine kinases. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 75 kDa

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Maintenance of Protein Location