Ezrin anticorps (AA 391-515)
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- Antigène Voir toutes Ezrin (EZR) Anticorps
- Ezrin (EZR)
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Épitope
- AA 391-515
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Reactivité
- Humain, Chien
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Ezrin est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- Réactivité croisée
- Chien
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human Ezrin aa. 391-515
- Clone
- 18-Ezrin
- Isotype
- IgG1
- Top Product
- Discover our top product EZR Anticorps primaire
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- Commentaires
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Related Products: ABIN968619, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20° C.
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Activation of the PKB/AKT pathway by ICAM-2." dans: Immunity, Vol. 16, Issue 1, pp. 51-65, (2002) (PubMed).
: "Inhibition of RhoA by p120 catenin." dans: Nature cell biology, Vol. 2, Issue 9, pp. 637-44, (2001) (PubMed).
: "Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes." dans: The EMBO journal, Vol. 19, Issue 2, pp. 199-212, (2000) (PubMed).
: "Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50." dans: The Journal of cell biology, Vol. 147, Issue 4, pp. 879-90, (1999) (PubMed).
: "Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis." dans: The Journal of cell biology, Vol. 131, Issue 5, pp. 1231-42, (1996) (PubMed).
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Activation of the PKB/AKT pathway by ICAM-2." dans: Immunity, Vol. 16, Issue 1, pp. 51-65, (2002) (PubMed).
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- Antigène
- Ezrin (EZR)
- Autre désignation
- Ezrin (EZR Produits)
- Synonymes
- anticorps CVIL, anticorps CVL, anticorps VIL2, anticorps ezr, anticorps vil2, anticorps wu:fc05c03, anticorps wu:fj31d06, anticorps cvil, anticorps cvl, anticorps Vil2, anticorps AW146364, anticorps R75297, anticorps p81, anticorps ezr.S, anticorps ezrin, anticorps ezrin b, anticorps ezrin L homeolog, anticorps EZR, anticorps ezrb, anticorps ezr, anticorps Ezr, anticorps ezr.L
- Sujet
- First described as an 80kDa protein concentrated in the apical cytoskeletal region of intestinal brush border cells, ezrin is now recognized as a major substrate of protein tyrosine kinases, such as the epidermal growth factor (EGF) tyrosine kinase. Ezrin is expressed at high levels in intestine, kidney, and placenta. In placenta, ezrin is present as monomers and non-covalent oligomers in tight association with actin microfilaments. In the human epidermoid carcinoma cell line A431, microvilli-like structures appear within 30 seconds after the addition of EGF. These structures give way to membrane ruffles after 2-5 minutes, followed by cell rounding after 10-20 minutes. At the same time, ezrin is recruited into these structures and oligomers are formed following its tyrosine phosphorylation. It is thought that tyrosine phosphorylation triggers the formation of ezrin oligomers.
- Poids moléculaire
- 80 kDa
- Pathways
- Maintenance of Protein Location
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