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SMAD2 anticorps (AA 27-172)

SMAD2 Reactivité: Humain, Souris, Rat WB, IHC, IF, IP Hôte: Souris Monoclonal 48-MAD2 unconjugated
N° du produit ABIN968105
  • Antigène Voir toutes SMAD2 Anticorps
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    Épitope
    • 47
    • 37
    • 30
    • 26
    • 21
    • 16
    • 9
    • 9
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 27-172
    Reactivité
    • 237
    • 151
    • 118
    • 12
    • 12
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 239
    • 11
    Souris
    Clonalité
    • 213
    • 37
    Monoclonal
    Conjugué
    • 128
    • 18
    • 12
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    Cet anticorp SMAD2 est non-conjugé
    Application
    • 212
    • 101
    • 64
    • 53
    • 52
    • 45
    • 41
    • 40
    • 18
    • 14
    • 11
    • 10
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human MAD2 aa. 27-172
    Clone
    48-MAD2
    Isotype
    IgG2a
    Top Product
    Discover our top product SMAD2 Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Babu, Jeganathan, Baker, Wu, Kang-Decker, van Deursen: "Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation." dans: The Journal of cell biology, Vol. 160, Issue 3, pp. 341-53, (2003) (PubMed).

    Iwanaga, Kasai, Kibler, Jeang: "Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function." dans: The Journal of biological chemistry, Vol. 277, Issue 34, pp. 31005-13, (2002) (PubMed).

    Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).

    Chen, Waters, Salmon, Murray: "Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores." dans: Science (New York, N.Y.), Vol. 274, Issue 5285, pp. 242-6, (1996) (PubMed).

  • Antigène
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    Autre désignation
    hsMAD2 (SMAD2 Produits)
    Synonymes
    anticorps JV18, anticorps JV18-1, anticorps MADH2, anticorps MADR2, anticorps hMAD-2, anticorps hSMAD2, anticorps jv18, anticorps Xmad2, anticorps madh2, anticorps madr2, anticorps XSmad2, anticorps hmad-2, anticorps hsmad2, anticorps jv18-1, anticorps smad-2, anticorps fj43c06, anticorps wu:fj43c06, anticorps 7120426M23Rik, anticorps Madh2, anticorps Madr2, anticorps Smad-2, anticorps mMad2, anticorps MAD homolog 2, anticorps Mothers against DPP homolog 2, anticorps SMAD 2, anticorps Smad2, anticorps SMAD family member 2, anticorps SMAD family member 2-Z, anticorps SMAD family member 2 S homeolog, anticorps SMAD2, anticorps SMAD2Z, anticorps smad2, anticorps smad2.S, anticorps Smad2
    Sujet
    Progression of the mammalian cell cycle is regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. These events are of utmost importance at the checkpoints, or transition points, of the cell cycle. MAD2 (Mitotic Arrest Deficient) is the human homolog of a yeast and Xenopus protein that is essential for spindle assembly during mitosis. The human hsMAD2 gene encodes a protein of 205 amino acids with a predicted molecular weight of 23.5 kDa. Binding of affinity purified polyclonal antibodies to the MAD2 protein prevents mitosis of HeLa cells. This indicates that, like its invertebrate relatives, MAD2 is necessary for mitosis. Furthermore, MAD2 is localized at the kinetochore of condensed chromosomes during mitosis and cells defective in the mitotic checkpoint have reduced levels of MAD2.
    Synonyms: Mitotic Arrest Deficient-2
    Poids moléculaire
    24 kDa
    Pathways
    Cycle Cellulaire, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
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