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Rab4 anticorps (AA 97-213)

RAB4A Reactivité: Humain, Souris, Rat, Chien WB, IF Hôte: Souris Monoclonal 7-Rab4 unconjugated
N° du produit ABIN968232
  • Antigène Voir toutes Rab4 (RAB4A) Anticorps
    Rab4 (RAB4A) (RAB4A, Member RAS Oncogene Family (RAB4A))
    Épitope
    • 16
    • 16
    • 7
    • 1
    • 1
    • 1
    AA 97-213
    Reactivité
    • 68
    • 42
    • 24
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien
    Hôte
    • 58
    • 8
    • 2
    Souris
    Clonalité
    • 51
    • 17
    Monoclonal
    Conjugué
    • 29
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Rab4 est non-conjugé
    Application
    • 50
    • 20
    • 17
    • 16
    • 15
    • 14
    • 14
    • 13
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Rat (Rattus), Chien, Souris
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human Rab4 aa. 97-213
    Clone
    7-Rab4
    Isotype
    IgG1
    Top Product
    Discover our top product RAB4A Anticorps primaire
  • Commentaires

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Steiner, Sarria, Glauser, Magnin, Catsicas, Hirling: "Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD." dans: The Journal of cell biology, Vol. 157, Issue 7, pp. 1197-209, (2002) (PubMed).

    Sans, Racca, Petralia, Wang, McCallum, Wenthold: "Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 19, pp. 7506-16, (2001) (PubMed).

    Cormont, Bortoluzzi, Gautier, Mari, van Obberghen, Le Marchand-Brustel: "Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes." dans: Molecular and cellular biology, Vol. 16, Issue 12, pp. 6879-86, (1997) (PubMed).

    Zahraoui, Touchot, Chardin, Tavitian: "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion." dans: The Journal of biological chemistry, Vol. 264, Issue 21, pp. 12394-401, (1989) (PubMed).

  • Antigène
    Rab4 (RAB4A) (RAB4A, Member RAS Oncogene Family (RAB4A))
    Autre désignation
    Rab4 (RAB4A Produits)
    Synonymes
    anticorps rab4a, anticorps MGC52945, anticorps fc93b03, anticorps wu:fc93b03, anticorps RAB4A, anticorps HRES-1/RAB4, anticorps RAB4, anticorps AI848268, anticorps Rab4, anticorps RAB4A, member RAS oncogene family, anticorps RAB4a, member RAS oncogene family, anticorps rab4a, anticorps RAB4A, anticorps Rab4a
    Sujet
    The Rab proteins are small GTP-binding molecules that are localized to specific intracellular vesicles and organelles and are important for vesicular trafficking. The Rab proteins cycle between active GTP-bound and inactive GDP-bound states. Rab4 is associated with early endosomes and recycling vesicles. It is involved in the recycling of receptors to the plasma membrane and regulates membrane recycling from early endosomes. Rab4 has been reported to be membrane-bound during interphase. However, it can be found as a cytosolic protein during mitosis. It is thought that Rab4 is phosphorylated by cdc2/cyclin B during mitosis and that Ser196 on Rab4 is the recognition site of cdc2. Mutation of Ser196 results in Rab4 membrane association during mitosis in an unphosphorylated form. Together this data indicates that Rab4 is phosphorylated by cdc2 on Ser196 which releases it into the cytosol during mitosis. In addition, Rab4 may play a role in insulin-induced glucose transport into rat adipocytes. Rab4 has also been reported to be associated with vesicles that contain GLUT4, a glucose transporter isoform. This antibody is routinely tested by western blot analysis.
    Poids moléculaire
    25 kDa
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