N-Cadherin anticorps (AA 802-819)

N° du produit ABIN968249

Détail du produit anti-N-Cadherin anticorps

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Épitope: AA 802-819

Reactivité: Humain, Souris, Rat, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp N-Cadherin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Humain, Rat (Rattus), Poulet

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse N-Cadherin aa. 802-819

Clone: 32-N

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968535

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-N-Cadherin (ABIN968249)

Burns, Collado, Oliver, Corwin: "Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes." dans: The Journal of comparative neurology, Vol. 521, Issue 6, pp. 1430-48, (2013) (PubMed).

Yamamori, Itakura, Sugaya, Katsumata, Sakagami, Takahashi: "Differential expression of SNAP-25 family proteins in the mouse brain." dans: The Journal of comparative neurology, Vol. 519, Issue 5, pp. 916-32, (2011) (PubMed).

Seki, Namba, Mochizuki, Onodera: "Clustering, migration, and neurite formation of neural precursor cells in the adult rat hippocampus." dans: The Journal of comparative neurology, Vol. 502, Issue 2, pp. 275-90, (2007) (PubMed).

Akins, Benson, Greer: "Cadherin expression in the developing mouse olfactory system." dans: The Journal of comparative neurology, Vol. 501, Issue 4, pp. 483-97, (2007) (PubMed).

Izawa, Nishizawa, Ohtakara, Inagaki: "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5345-50, (2002) (PubMed).

Nürnberger, Bacallao, Phillips: "Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells." dans: Molecular biology of the cell, Vol. 13, Issue 9, pp. 3096-106, (2002) (PubMed).

Miyatani, Shimamura, Hatta, Nagafuchi, Nose, Matsunaga, Hatta, Takeichi: "Neural cadherin: role in selective cell-cell adhesion." dans: Science (New York, N.Y.), Vol. 245, Issue 4918, pp. 631-5, (1989) (PubMed).

Détails sur N-Cadherin

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Autre désignation: N-Cadherin (CDH2 Produits)

Synonymes: anticorps CD325, anticorps CDHN, anticorps CDw325, anticorps NCAD, anticorps N-cadherin, anticorps cadherin-2, anticorps cdhn, anticorps ncad, anticorps cdw325, anticorps CDH2, anticorps Cadherin-2, anticorps Ncad, anticorps glo, anticorps lyr, anticorps pac, anticorps wu:fb47h04, anticorps cadherin 2, anticorps cadherin 2 S homeolog, anticorps cadherin 2, type 1, N-cadherin (neuronal), anticorps CDH2, anticorps cdh2.S, anticorps cdh2, anticorps Cdh2

Sujet: Cadherins are a family of Ca2+-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenins (alpha, beta, gamma). Members of the cadherin family include P-cadherin, E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-cadherin, cadherin 5, L-CAM, and EP-cadherin. N-cadherin mRNA is found at elevated levels in brain and heart and at a much lower level in liver. Mechanisms such as mRNA expression, cytokine modulation, and protease-mediated turnover modulate N-cadherin protein levels during development. In addition, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of beta-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, N-cadherin also interacts with a PTP1B-like phosphatase that dephosphorylates beta-catenin and promotes N-cadherin/actin association. Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.

Poids moléculaire: 130 kDa

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane