Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

Aurora A anticorps (AA 8-116)

AURKA Reactivité: Humain, Souris, Rat WB, IF Hôte: Souris Monoclonal 4-IAK1 unconjugated
N° du produit ABIN968261
  • Antigène Voir toutes Aurora A (AURKA) Anticorps
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Épitope
    • 28
    • 22
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 8-116
    Reactivité
    • 126
    • 73
    • 41
    • 20
    • 18
    • 14
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain, Souris, Rat
    Hôte
    • 123
    • 20
    • 1
    Souris
    Clonalité
    • 110
    • 33
    Monoclonal
    Conjugué
    • 82
    • 10
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Aurora A est non-conjugé
    Application
    • 105
    • 59
    • 37
    • 25
    • 19
    • 15
    • 12
    • 11
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Humain, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse IAK1 aa. 8-116
    Clone
    4-IAK1
    Isotype
    IgG1
    Top Product
    Discover our top product AURKA Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Kiat, Hui, Gopalan: "Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase." dans: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45558-65, (2002) (PubMed).

    Sakai, Urano, Ookata, Kim, Hirai, Saito, Nojima, Ishikawa: "MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase." dans: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48714-23, (2002) (PubMed).

    Katayama, Ota, Jisaki, Ueda, Tanaka, Odashima, Suzuki, Terada, Tatsuka: "Mitotic kinase expression and colorectal cancer progression." dans: Journal of the National Cancer Institute, Vol. 91, Issue 13, pp. 1160-2, (1999) (PubMed).

    Gopalan, Chan, Donovan: "A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators." dans: The Journal of cell biology, Vol. 138, Issue 3, pp. 643-56, (1997) (PubMed).

  • Antigène
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Autre désignation
    IAK1 (AURKA Produits)
    Synonymes
    anticorps AIK, anticorps ARK1, anticorps AURA, anticorps AURORA2, anticorps BTAK, anticorps PPP1R47, anticorps STK15, anticorps STK6, anticorps STK7, anticorps AIRK1, anticorps AU019385, anticorps AW539821, anticorps Ark1, anticorps Aurora-A, anticorps Ayk1, anticorps IAK, anticorps IAK1, anticorps Stk6, anticorps 87A7-9/2, anticorps Aur-A, anticorps AurA, anticorps CG3068, anticorps Dmel\\CG3068, anticorps aur-A, anticorps aurA, anticorps ck10, anticorps ck[10], anticorps l(3)87Ac, anticorps l(3)ck10, anticorps ARK-1, anticorps Eg2, anticorps aik, anticorps ark1, anticorps aur-a, anticorps aura, anticorps aurka-a, anticorps aurora2, anticorps btak, anticorps stk15, anticorps stk6, anticorps stk7, anticorps pEg2, anticorps wu:fb37c10, anticorps wu:fc02c02, anticorps zgc:100912, anticorps AURKA, anticorps aurka, anticorps aurora kinase A, anticorps aurora A, anticorps aurora kinase A L homeolog, anticorps hypothetical protein, anticorps aurora kinase A S homeolog, anticorps AURKA, anticorps Aurka, anticorps aurA, anticorps aurka.L, anticorps aurka, anticorps Aurora-A, anticorps aurka.S
    Sujet
    Cell division is a tightly regulated process that ensures the segregation of chromosomes into daughter cells. Essential to this regulation is the modification of cell cycle components by reversible phosphorylation. Ipl1 and aurora are two related kinases isolated from S.cerevisiae and Drosophila, respectively. Inactivation of these kinases results in abnormal chromosome segregation and disruption of the centrosome. A structurally and functionally similar kinase, IAK1 (Ipl1- and Aurora-related kinase 1), is a regulator of mammalian chromosome segregation. Although IAK1 may be present in the cytoplasm, it is detected on the centrosome following duplication and also associates with the spindle microtubules from metaphase through cell division. Expression of IAK1 is stringently regulated during the cell cycle. Both mRNA and protein are initially expressed in S-phase, are elevated during M-phase, and are undetectable following completion of mitosis. Increasing evidence suggests that IAK1 belongs to a novel subfamily of the ser/thr kinase superfamily. Although mutational analysis of IAK1 will directly determine its function, it appears to be a key player in the control of cell division.
    Synonyms: Aurora-A Kinase
    Poids moléculaire
    46 kDa
    Pathways
    Cycle Cellulaire, Asymmetric Protein Localization
Vous êtes ici:
Support technique